Article: KCNQ/M channels control spike afterdepolarization and burst generation in hippocampal neurons.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Yue C; Yaari Y J. Neurosci., 2004
Control (n = 20) | Linopirdine (n = 20) | Control (n = 7) | XE991 (n = 7) | Control (n = 5) | Retigabine (n = 5) | |
---|---|---|---|---|---|---|
Resting potential (mV) | −69.9 ± 3.3* | −64.7 ± 4.8* | −67.7 ± 3.2 | −65.6 ± 3.2 | −68.0 ± 2.1* | −72.8 ± 3.2* |
Input resistance (MΩ) | 35.4 ± 11.7* | 40.3 ± 16.6* | 38.9 ± 11.6 | 44.7 ± 16.1 | 40.1 ± 11.3* | 24.8 ± 3.1* |
Spike threshold (mV) | −58.9 ± 2.8 | −56.9 ± 3.9 | −62.5 ± 5.1 | −61.8 ± 4.4 | −63.5 ± 3.8 | −60.2 ± 4.8 |
Spike rise time (msec) | 0.16 ± 0.49 | 0.14 ± 0.3 | 0.15 ± 0.4 | 0.14 ± 0.24 | 0.14 ± 0.23 | 0.15 ± 0.25 |
Spike amplitude (mV) | 92.0 ± 7.0 | 93.6 ± 6.6 | 96.6 ± 6.7 | 97.9 ± 7.5 | 96.6 ± 5.5 | 98.1 ± 3.6 |
Spike width (msec) | 0.83 ± 0.09* | 0.95 ± 0.17* | 0.84 ± 0.62* | 0.90 ± 0.3* | 0.85 ± 0.1* | 0.97 ± 0.1* |
Fast AHP (msec) | −60.1 ± 3.3* | −57.7 ± 3.4* | −61.9 ± 4.9* | −60.2 ± 4.5* | −62.4 ± 2.6 | −59.4 ± 3.5 |
ADP size (mV·msec) | 180.3 ± 40.1* | 295.2 ± 89.9* | 180.9 ± 77.8* | 287.6 ± 109.8* | 203.5 ± 58.2* | 132.2 ± 61.3* |
-
The asterisks denote significant differences between mean values in controls versus the drug-treated group (paired Student's t test; p < 0.05).