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Article: The nitric oxide-guanylyl cyclase signaling pathway modulates membrane activity States and electrophysiological properties of striatal medium spiny neurons recorded in vivo.

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West AR; Grace AA
J. Neurosci., 2004


Table 2.

Effects of intracellular manipulations of cGMP levels on the membrane properties of striatal neurons

Membrane properties Control ODQ ODQ+cGMP Zaprinast
Firing rate (Hz) 0.54 ± 0.33 0.06 ± 0.06 0.05 ± 0.04 0.91 ± 0.35**
(p<0.05)
Average MP (mV) -78.2 ± 2.7 -84.7 ± 2.3 -79.2 ± 2.7 -65.0 ± 0.76*
(p<0.05)
Up-state frequency (Hz) 1.17 ± 0.11 1.03 ± 0.14 0.90 ± 0.06 0.97 ± 0.06
Maximal depolarized MPa (mV) -55.0 ± 3.5 -72.2 ± 2.5* -55.0 ± 2.0 -44.4 ± 2.7*
(p<0.05) (p<0.05)
Up-state mode (mV) -73.0 ± 4.2 -81.4 ± 4.0 -75.8 ± 1.8 -61.2 ± 1.7*
(p<0.05)
Down-state mode (mV) -83.0 ± 3.8 -87.4 ± 4.6 -87.0 ± 1.4 -72.0 ± 3.7
Maximal hyperpolarized MP (mV) -91.3 ± 3.2 -90.8 ± 3.1 -91.8 ± 1.4 -80.4 ± 2.9*
(p<0.05)
Input resistance (mΩ) 34.3 ± 1.8 17.7 ± 3.5* 20.3 ± 1.0 28.4 ± 1.8
(p<0.05)
Action potential Amplitude (mV) 70.0 ± 2.4 60.0 ± 2.4* 68.2 ± 3.1 71.6 ± 2.5
(p<0.05)
Overshoot (mV) +22.1 ± 2.8 +14.7 ± 2.7 +22.5 ± 1.6 +25.9 ± 3.5
Duration (msec) 1.2 ± 0.08 1.3 ± 0.05 1.1 ± 0.07 1.2 ± 0.05
Threshold (mV) -47.5 ± 1.2 -45.7 ± 3.0 -45.6 ± 2.2 -45.7 ± 1.5
AHP (mV) -12.5 ± 1.6 -12.3 ± 2.4 -12.9 ± 0.4 -10.9 ± 1.4
  • All data are means ± SEM from n = 5-6 neurons. MP, Membrane potential; AHP, afterhyperpolarization.

  • * Statistical significance was determined by comparing DMSO control to drug groups using an ANOVA with Dunnett's post hoc test.

  • ** Significantly different compared to the ODQ group using an ANOVA with Dunnett's post hoc test.

  • a This calculation does not include membrane potential fluctuations contributed by action potentials.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neostriatum medium spiny neuron input resistance (mΩ) 34.3 ± 1.8 (5) 34.3 (MΩ) Data Table
Neostriatum medium spiny neuron spike amplitude (mV) 70.0 ± 2.4 (5) 70.0 (mV) Data Table
Neostriatum medium spiny neuron spike peak (mV) 22.1 ± 2.8 (5) 22.1 (mV) Data Table
Neostriatum medium spiny neuron spike width (msec) 1.2 ± 0.08 (5) 1.2 (ms) Data Table
Neostriatum medium spiny neuron spike threshold (mV) -47.5 ± 1.2 (5) -47.5 (mV) Data Table
Neostriatum medium spiny neuron AHP amplitude (mV) -12.5 ± 1.6 (5) 12.5 (mV) Data Table
Neostriatum medium spiny neuron firing frequency (Hz) 0.54 ± 0.33 (5) 0.54 (Hz) Data Table
Neostriatum medium spiny neuron resting membrane potential (mV) -78.2 ± 2.7 (5) -78.2 (mV) Data Table