AboutNeuron TypesElectrophysiology PropertiesArticlesFAQsData/APIGet Involved

Article: Long-term K+ channel-mediated dampening of dopamine neuron excitability by the antipsychotic drug haloperidol.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Hahn J; Tse TE; Levitan ES
J. Neurosci., 2003


Table 1.

Action potential properties of DA neurons after chronic haloperidol treatment

Half-width (msec) First peak (mV) Second peak (mV) Threshold (mV) AHP (mV)
Without TEA
Control 3.2 ± 1.4 33.1 ± 3.1 30.5 ± 2.1 −44.5 ± 0.9 −56.2 ± 1.5
Vehicle 3.3 ± 0.9 32.1 ± 3.4 32.4 ± 4.6 −45.0 ± 1.4 −57.9 ± 2.1
Haloperidol 4.3 ± 1.3 35.4 ± 3.2 33.6 ± 3.5 −46.1 ± 1.2 −58.9 ± 1.6
With TEA
Control 185 ± 62 21.0 ± 1.7 20.7 ± 2.4 −43.2 ± 2.4 −45.2 ± 2.6
Vehicle 155 ± 88 27.5 ± 2.6 25.7 ± 5.7 −38.9 ± 4.6 −48.4 ± 2.2
Haloperidol 126 ± 55 27.9 ± 1.5 24.6 ± 4.5 −40.5 ± 3.2 −53.7 ± 1.6
  • Half-width, The time between two peaks of first derivative; first peak, peak of the first spike; second peak, peak of the second spike; threshold, the first point on the rising phase of the spike where the rate of rise exceeded 20 mV/msec; AHP, afterhyperpolarization. n = 5-6.


Report miscurated data

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Ventral tegmental area dopamine neuron midbrain dopaminergic neuron spike threshold (mV) -44.5 ± 0.9 (5) -44.5 (mV) Data Table
Ventral tegmental area dopamine neuron midbrain dopaminergic neuron AHP amplitude (mV) -56.2 ± 1.5 (5) -- Data Table
Ventral tegmental area dopamine neuron midbrain dopaminergic neuron spike half-width (msec) 3.2 ± 1.4 (5) 3.2 (ms) Data Table
Ventral tegmental area dopamine neuron midbrain dopaminergic neuron spike peak (mV) 33.1 ± 3.1 (5) 33.1 (mV) Data Table