Article: Long-term K+ channel-mediated dampening of dopamine neuron excitability by the antipsychotic drug haloperidol.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Hahn J; Tse TE; Levitan ES J. Neurosci., 2003
Half-width (msec) | First peak (mV) | Second peak (mV) | Threshold (mV) | AHP (mV) | |
---|---|---|---|---|---|
Without TEA | |||||
Control | 3.2 ± 1.4 | 33.1 ± 3.1 | 30.5 ± 2.1 | −44.5 ± 0.9 | −56.2 ± 1.5 |
Vehicle | 3.3 ± 0.9 | 32.1 ± 3.4 | 32.4 ± 4.6 | −45.0 ± 1.4 | −57.9 ± 2.1 |
Haloperidol | 4.3 ± 1.3 | 35.4 ± 3.2 | 33.6 ± 3.5 | −46.1 ± 1.2 | −58.9 ± 1.6 |
With TEA | |||||
Control | 185 ± 62 | 21.0 ± 1.7 | 20.7 ± 2.4 | −43.2 ± 2.4 | −45.2 ± 2.6 |
Vehicle | 155 ± 88 | 27.5 ± 2.6 | 25.7 ± 5.7 | −38.9 ± 4.6 | −48.4 ± 2.2 |
Haloperidol | 126 ± 55 | 27.9 ± 1.5 | 24.6 ± 4.5 | −40.5 ± 3.2 | −53.7 ± 1.6 |
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Half-width, The time between two peaks of first derivative; first peak, peak of the first spike; second peak, peak of the second spike; threshold, the first point on the rising phase of the spike where the rate of rise exceeded 20 mV/msec; AHP, afterhyperpolarization. n = 5-6.
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
---|---|---|---|---|---|
Ventral tegmental area dopamine neuron | midbrain dopaminergic neuron | spike threshold (mV) | -44.5 ± 0.9 (5) | -44.5 (mV) | Data Table |
Ventral tegmental area dopamine neuron | midbrain dopaminergic neuron | AHP amplitude (mV) | -56.2 ± 1.5 (5) | -- | Data Table |
Ventral tegmental area dopamine neuron | midbrain dopaminergic neuron | spike half-width (msec) | 3.2 ± 1.4 (5) | 3.2 (ms) | Data Table |
Ventral tegmental area dopamine neuron | midbrain dopaminergic neuron | spike peak (mV) | 33.1 ± 3.1 (5) | 33.1 (mV) | Data Table |