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Article: Antiepileptic efficacy of topiramate: assessment in two in vitro seizure models.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Jahromi SS; Pelletier MR; McDonald PJ; Khosravani H; Carlen PL
Brain Res., 2000


Table 1Topiramate does not affect intrinsic membrane propertiesin CA1 pyramidal neuronsa
VariableControlTopiramate (100 μM)
Resting membrane potential (mV)−62.3±1.8−61.8±2.1
(10)(12)
Input resistance (MΩ)47.8±12.756.2±15.3
(10)(12)
Spike amplitude (mV)106.3±2.8107.4±2.9
(10)(13)
Spike threshold (mV)40.6±1.639.0±1.7
(10)(12)
Fast afterhyperpolarization (mV)−13.9±0.9−11.9±0.9
(9)(7)
Slow afterhyperpolarization (mV)−11.3±0.8−9.5±1.2
(9)(7)
Afterdepolarization (mV)11.8±0.811.1±1.4
(10)(12)
aNumber in parentheses denotes number of neurons.

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 pyramidal cell Hippocampus CA1 pyramidal neuron input resistance (MΩ) 47.8 ± 12.7 (10) 47.8 (MΩ) Data Table
Hippocampus CA1 pyramidal cell Hippocampus CA1 pyramidal neuron spike amplitude (mV) 106.3 ± 2.8 (10) 106.3 (mV) Data Table
Hippocampus CA1 pyramidal cell Hippocampus CA1 pyramidal neuron spike threshold (mV) 40.6 ± 1.6 (10) -40.6 (mV) Data Table
Hippocampus CA1 pyramidal cell Hippocampus CA1 pyramidal neuron fast AHP amplitude (mV) -13.9 ± 0.9 (10) 13.9 (mV) Data Table
Hippocampus CA1 pyramidal cell Hippocampus CA1 pyramidal neuron slow AHP amplitude (mV) -11.3 ± 0.8 (10) 11.3 (mV) Data Table
Hippocampus CA1 pyramidal cell Hippocampus CA1 pyramidal neuron ADP amplitude (mV) 11.8 ± 0.8 (10) 11.8 (mV) Data Table
Hippocampus CA1 pyramidal cell Hippocampus CA1 pyramidal neuron resting membrane potential (mV) -62.3 ± 1.8 (10) -62.3 (mV) Data Table