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Article: Maturation of EPSCs and intrinsic membrane properties enhances precision at a cerebellar synapse.

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Cathala L; Brickley S; Cull-Candy S; Farrant M
J. Neurosci., 2003


Table 1.

Properties of quantal EPSCs in immature and mature GCs

Immature (P8) Mature (P39)
Frequency (Hz) 0.6 ± 0.2 1.0 ± 0.4
AMPAR-mediated component (−70 mV)
Amplitude (pA) 21.7 ± 2.3 19.7 ± 1.0
10-90% rise time (msec) 0.20 ± 0.01 0.15 ± 0.01*
τdecay (msec) 1.47 ± 0.17 0.79 ± 0.06*
τfast (msec) 0.66 ± 0.05 0.43 ± 0.04*
τslow (msec) 6.91 ± 1.71 4.38 ± 1.02
Afast (%) 88.9 ± 1.8 91.4 ± 1.3
Charge transfer (fC) 34.8 ± 3.5 19.2 ± 2.3*
NMDAR-mediated component (−25 mV)
Amplitude (pA) 3.1 ± 0.6
10-90% rise time (msec) 0.86 ± 0.29
τdecay (msec) 18.2 ± 8.1
Charge transfer (fC) 61.4 ± 18.8
  • Measurements are from 10 cells at each age (except for NMDA data, where n = 5). *Significant differences (p < 0.05). Horizontal bars indicate absence of NMDAR-mediated component in mature GCs.


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