Article: High serotonin levels during brain development alter the structural input-output connectivity of neural networks in the rat somatosensory layer IV.

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Miceli S; Negwer M; van Eijs F; Kalkhoven C; van Lierop I; Homberg J; Schubert D
Front Cell Neurosci, 2013

Table 2

Electrophysiological properties of Layer IV excitatory neurons.

	SERT^+/+		SERT^-/-
	Pyramidal cell	Spiny stellate cell	Pyramidal cell	Spiny stellate cell
PASSIVE PROPERTIES	n = 22	n = 10	n = 30	n = 11
V_rmp [mV]	69.2 ± 1.4	-67.4 ± 1.9	-70.6 ± 1.4	-67.7 ± 2.1
R_m [MΩ]	142.5 ± 11.8	157.9 ± 23.4	128.0 ± 13.7	145.8 ± 17.6
τ_m [ms]	15.8 ± 1.3	15.8 ± 1.8	15.9 ± 1.2	16.1 ± 1.6
ACTIVE PROPERTIES
AP threshold¹ [mV]	-37.4 ± 1.3	-31.6 ± 1.4	-37.0 ± 1.1	-36.8 ± 2.4
AP amplitude [mV]	77.6 ± 9.9	69.5 ± 5.0	78.2 ± 9.3	76.4 ± 12.7
AP halfwidth [ms]	1.3 ± 0.4	1.4 ± 0.2	1.4 ± 0.3	1.3 ± 0.3
1st ISI – weak¹ [ms]	27.2 ± 5.9	28.7 ± 8.4	43.6 ± 8.8	24.3 ± 8.9
1st ISI – strong² [ms]	9.0 ± 0.8	7.3 ± 1.0	10.3 ± 1.1	13.7 ± 3.7
AP FIRING PATTERN
Regular spiking	54.5%	40%	73.3%	36.4%
Instrinsic bursting	45.5%	60%	26.7%	63.6%

Active properties were measured by

just suprathreshold stimulation, eliciting 2–4 APs, or

by stronger depolarizing current injection, eliciting 10–14 APs. No significant differences were found between SpSt and Pyr across both genotypes. Data are means ± SEM. Pyr, pyramidal cell; SpSt, spiny stellate cell; ISI, inter-stimulus interval.

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Inferred neuron-electrophysiology data values

Neuron Type	Neuron Description	Ephys Prop	Extracted Value	Standardized Value	Content Source
Neocortex uncharacterized cell	Layer 4 barrel cortex pyramidal cell	input resistance	142.5 ± 11.8 (22)	142.5 (MΩ)	Data Table
Neocortex layer 4 stellate cell	Layer 4 barrel cortex spiny stellate cell	input resistance	157.9 ± 23.4 (10)	157.9 (MΩ)	Data Table
Neocortex uncharacterized cell	Layer 4 barrel cortex pyramidal cell	membrane time constant	15.8 ± 1.3 (22)	15.8 (ms)	Data Table
Neocortex layer 4 stellate cell	Layer 4 barrel cortex spiny stellate cell	membrane time constant	15.8 ± 1.8 (10)	15.8 (ms)	Data Table
Neocortex uncharacterized cell	Layer 4 barrel cortex pyramidal cell	spike threshold	-37.4 ± 1.3 (22)	-37.4 (mV)	Data Table
Neocortex layer 4 stellate cell	Layer 4 barrel cortex spiny stellate cell	spike threshold	-31.6 ± 1.4 (10)	-31.6 (mV)	Data Table
Neocortex uncharacterized cell	Layer 4 barrel cortex pyramidal cell	spike amplitude	77.6 ± 9.9 (22)	77.6 (mV)	Data Table
Neocortex layer 4 stellate cell	Layer 4 barrel cortex spiny stellate cell	spike amplitude	69.5 ± 5.0 (10)	69.5 (mV)	Data Table
Neocortex uncharacterized cell	Layer 4 barrel cortex pyramidal cell	spike half-width	1.3 ± 0.4 (22)	1.3 (ms)	Data Table
Neocortex layer 4 stellate cell	Layer 4 barrel cortex spiny stellate cell	spike half-width	1.4 ± 0.2 (10)	1.4 (ms)	Data Table
Neocortex uncharacterized cell	Layer 4 barrel cortex pyramidal cell	resting membrane potential	69.2 ± 1.4 (22)	-69.2 (mV)	Data Table
Neocortex layer 4 stellate cell	Layer 4 barrel cortex spiny stellate cell	resting membrane potential	-67.4 ± 1.9 (10)	-67.4 (mV)	Data Table