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Article: GluN2D-containing NMDA receptors-mediate synaptic currents in hippocampal interneurons and pyramidal cells in juvenile mice.

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von Engelhardt J; Bocklisch C; Tönges L; Herb A; Mishina M; Monyer H
Front Cell Neurosci, 2015


NMDAR-mediated currents.

P3-5 P9-11 P20-25
EGFP-GLUN2D-POS. CELLS
Remaining current in the presence of ifenprodil (%) 45 ± 20n = 14 63 ± 24n = 9 60 ± 24n = 5
τdecay (ms) 253 [214–342]n = 23 227 [181–269]n = 30 177 [129–252]n = 11
τdecay + ifenprodil (ms) 378 [260–401]n = 16* 311 [223–397]n = 19* 177 [118–272]n = 11
PYRAMIDAL CELLS
Remaining current in the presence of ifenprodil (%) 32 ± 16n = 12 47 ± 21n = 8 72 ± 21n = 10
τdecay (ms) 312 [246-339]n = 26 254 [221–268]n = 23 241 [217–273]n = 15
τdecay + ifenprodil (ms) 361 [271–601]n = 43* 215 [180–227]n = 22** 187 [168–219]n = 15**
PV-POSITIVE CELLS
Remaining current in the presence of ifenprodil (%) 49 ± 17n = 6
τdecay (ms) 230 [179–296]n = 31
τdecay + ifenprodil (ms) 268 [211–356]n = 40*
GRIN2D-/- INTERNEURON
Remaining current in the presence of ifenprodil (%) 25 ± 20n = 13
τdecay (ms) 323 [253–349]n = 21
τdecay + ifenprodil (ms) 303 [224–376]n = 14
GRIN2D-/- PYRAMIDAL CELLS
Remaining current in the presence of ifenprodil (%) 37 ± 17n = 17
τdecay (ms) 361 [302–398]n = 20
τdecay + ifenprodil (ms) 267 [230–307]n = 11**

Mean ± SD are shown for the percentage of remaining current in the presence of ifenprodil and median ± interquartile range [IQR]) for the decay time constants (τdecay). Statistical differences between the τdecay in the absence and presence of ifenprodil were examined by Mann–Whitney U-test (

p < 0.05,

p < 0.01).


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source