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Article: Diversity of layer 5 projection neurons in the mouse motor cortex.

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Oswald MJ; Tantirigama ML; Sonntag I; Hughes SM; Empson RM
Front Cell Neurosci, 2013


Electrophysiological properties of M1 layer 5 projection neurons (26°C).

CSp (n = 26) CTh (n = 23) CStr (n = 25) CC (n = 25) Statistics‡
Membrane potential (mV) -64.9 (-61.4, -67.3) -68.0 (-63.9, -69.9) -67.9 (-63.9, -71.3) -69.9 (-67.8, -70.6) b 1, c 2
Input resistance (MΩ) 111 (78, 132) 85 (71, 111) 221 (168, 330) 209 (136, 266) b 3, c 3, d 2, e 3
Membrane Tau (ms) 27.7 (21.2, 30.9) 20.5 (16.1, 24.3) 33.0 (29.0, 40.4) 34.4 (30.3, 46.7) a 1, c 2, d 3, e 3
Sag ∫ 0.30 (0.23, 0.38) 0.49 (0.42, 0.53) 0.10 (0.07, 0.14) 0.17 (0.08, 0.20) a 1, b 3, c 2, d 3, e 3
Post-train AHP (mV) -7.9 (-6.8, -9.5) -8.5 (-7.4, -9.4) -3.8 (-2.6, -5.7) -3.2 (-2.6, -4.6) b 3, c 3, d 3, e 3
Log adaptation § 3.56 ± 0.56 4.33 ± 0.14 2.45 ± 0.11 2.53 ± 0.09 a 3, b 3, c 3, d 3, e 3
Max mean inst freq (Hz) 39.2 (36.6, 45.8) 37.5 (31.3, 69.1) 39.4 (34.1, 44.7) 30.8 (26.5, 28.0) c 2, e 1, f 2
Max frequency (Hz) 34.1 (31.2, 38.6) 26.0 (22.6, 30.4) 29.2 (19.6, 33.1) 25.2 (22.3, 32.0) a 2, b 1, c 2
I 50% max frequency (pA) 273 (229, 333) 486 (323, 568) 214 (182, 289) 332 (211, 410) a 3, d 3, e 3, f 1
Frequency gain (Hz/pA) 0.082 ± 0.002 0.069 ± 0.002 0.088 ± 0.007 0.082 ± 0.005 p = 0.056

As for Table 1.

Sag potential of hyperpolarisation and cyclic nucleotide-activated current, normalized to peak potential.

Normalized data (absolute values of the natural Log of the adaptation index after adding a constant of 0.025 to each index to remove negative data values).
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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticostriatal pyramidal neuron input resistance (MΩ) 221.0 (25) 221.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticocortical pyramidal neuron input resistance (MΩ) 209.0 (25) 209.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticospinal thick tufted pyramidal neuron membrane time constant (ms) 27.7 (26) 27.7 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticothalamic thick tufted pyramidal neuron membrane time constant (ms) 20.5 (23) 20.5 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticostriatal pyramidal neuron membrane time constant (ms) 33.0 (25) 33.0 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticocortical pyramidal neuron membrane time constant (ms) 34.4 (25) 34.4 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticospinal thick tufted pyramidal neuron resting membrane potential (mV) -64.9 (26) -64.9 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticospinal thick tufted pyramidal neuron sag ratio 0.3 (26) 0.3 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticothalamic thick tufted pyramidal neuron sag ratio 0.49 (23) 0.49 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticostriatal pyramidal neuron sag ratio 0.1 (25) 0.1 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticocortical pyramidal neuron sag ratio 0.17 (25) 0.17 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticospinal thick tufted pyramidal neuron AHP amplitude (mV) -7.9 (26) 7.9 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticothalamic thick tufted pyramidal neuron AHP amplitude (mV) -8.5 (23) 8.5 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticostriatal pyramidal neuron AHP amplitude (mV) -3.8 (25) 3.8 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticocortical pyramidal neuron AHP amplitude (mV) -3.2 (25) 3.2 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticothalamic thick tufted pyramidal neuron resting membrane potential (mV) -68.0 (23) -68.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticospinal thick tufted pyramidal neuron adaptation ratio (other) 3.56 ± 0.56 (26) 3.56 (None) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticothalamic thick tufted pyramidal neuron adaptation ratio (other) 4.33 ± 0.14 (23) 4.33 (None) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticostriatal pyramidal neuron adaptation ratio (other) 2.45 ± 0.11 (25) 2.45 (None) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticocortical pyramidal neuron adaptation ratio (other) 2.53 ± 0.09 (25) 2.53 (None) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticostriatal pyramidal neuron resting membrane potential (mV) -67.9 (25) -67.9 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticospinal thick tufted pyramidal neuron maximum firing rate (Hz) 34.1 (26) 34.1 (Hz) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticothalamic thick tufted pyramidal neuron maximum firing rate (Hz) 26.0 (23) 26.0 (Hz) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticostriatal pyramidal neuron maximum firing rate (Hz) 29.2 (25) 29.2 (Hz) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticocortical pyramidal neuron maximum firing rate (Hz) 25.2 (25) 25.2 (Hz) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticocortical pyramidal neuron resting membrane potential (mV) -69.9 (25) -69.9 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticospinal thick tufted pyramidal neuron FI slope (Hz/pA) 0.082 ± 0.002 (26) 82.0 (Hz/nA) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticothalamic thick tufted pyramidal neuron FI slope (Hz/pA) 0.069 ± 0.002 (23) 69.0 (Hz/nA) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticostriatal pyramidal neuron FI slope (Hz/pA) 0.088 ± 0.007 (25) 88.0 (Hz/nA) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticocortical pyramidal neuron FI slope (Hz/pA) 0.082 ± 0.005 (25) 82.0 (Hz/nA) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticospinal thick tufted pyramidal neuron input resistance (MΩ) 111.0 (26) 111.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Primary motor cortex layer 5 corticothalamic thick tufted pyramidal neuron input resistance (MΩ) 85.0 (23) 85.0 (MΩ) Data Table