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Article: High temperatures alter physiological properties of pyramidal cells and inhibitory interneurons in hippocampus.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Kim JA; Connors BW
Front Cell Neurosci, 2012


Passive membrane properties of principal cells at hyperthermic temperatures.

CA1 pyramidal cells at 30°C CA1 pyramidal cells at 41°C CA3 pyramidal cells at 30°C CA3 pyramidal cells at 41°C Dentate granule cells at 30°C Dentate granule cells at 41°C
Vm (mV) -63.3 ± 0.9 -55.1 ± 2.4*** -62.1 ± 0.7 -47.7 ± 1.7*** -67.3 ± 1.8 -52.6 ± 2.4*
Rin (MΩ) 208 ± 24 167 ± 22*** 358 ± 19 271 ± 24*** 987 ± 118 788 ± 91***
τm (msec) 19.9 ± 1.3 21.9 ± 1.9 57.30 ± 2.5 45.7 ± 1.9** 34.8 ± 2.8 34.7 ± 1.5

All data are mean ± S.E.M; CA1 pyramidal (n = 19), CA3 pyramidal (n = 38), DG (n = 19);

p < 0.05,

p < 0.01,

p < 0.005. Vm: membrane potential, Rin: input resistance, τm: time-constant.
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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 pyramidal cell input resistance (MΩ) 167.0 ± 22.0 167.0 (MΩ) Data Table
Hippocampus CA3 pyramidal cell input resistance (MΩ) 358.0 ± 19.0 358.0 (MΩ) Data Table
Hippocampus CA3 pyramidal cell input resistance (MΩ) 271.0 ± 24.0 271.0 (MΩ) Data Table
Dentate gyrus granule cell input resistance (MΩ) 987.0 ± 118.0 987.0 (MΩ) Data Table
Dentate gyrus granule cell input resistance (MΩ) 788.0 ± 91.0 788.0 (MΩ) Data Table
Hippocampus CA1 pyramidal cell membrane time constant (msec) 19.9 ± 1.3 19.9 (ms) Data Table
Hippocampus CA1 pyramidal cell membrane time constant (msec) 21.9 ± 1.9 21.9 (ms) Data Table
Hippocampus CA3 pyramidal cell membrane time constant (msec) 57.3 ± 2.5 57.3 (ms) Data Table
Hippocampus CA3 pyramidal cell membrane time constant (msec) 45.7 ± 1.9 45.7 (ms) Data Table
Hippocampus CA1 pyramidal cell resting membrane potential (mV) -63.3 ± 0.9 -63.3 (mV) Data Table
Dentate gyrus granule cell membrane time constant (msec) 34.8 ± 2.8 34.8 (ms) Data Table
Dentate gyrus granule cell membrane time constant (msec) 34.7 ± 1.5 34.7 (ms) Data Table
Hippocampus CA1 pyramidal cell resting membrane potential (mV) -55.1 ± 2.4 -55.1 (mV) Data Table
Hippocampus CA3 pyramidal cell resting membrane potential (mV) -62.1 ± 0.7 -62.1 (mV) Data Table
Hippocampus CA3 pyramidal cell resting membrane potential (mV) -47.7 ± 1.7 -47.7 (mV) Data Table
Dentate gyrus granule cell resting membrane potential (mV) -67.3 ± 1.8 -67.3 (mV) Data Table
Dentate gyrus granule cell resting membrane potential (mV) -52.6 ± 2.4 -52.6 (mV) Data Table
Hippocampus CA1 pyramidal cell input resistance (MΩ) 208.0 ± 24.0 208.0 (MΩ) Data Table