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Article: Adult mouse basal forebrain harbors two distinct cholinergic populations defined by their electrophysiology.

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Unal CT; Golowasch JP; Zaborszky L
Front Behav Neurosci, 2012


Early- (EF) and Late-firing (LF) cell's physiological properties.

Early-firing Late-firing t p df
Mean ± SD Mean ± SD
First AP delay (ms) 107 ± 53 343 ± 76 -16.094 <0.001 101
(n = 70) (n = 33)
I-F slope (Hz/pA) 0.06 ± 0.04 0.03 ± 0.02 4.287 <0.001 101
Adaptation ratio 2.74 ± 2.57 1.33 ± 0.57 4.126 <0.001 93
Depolarization block (ms) 136 ± 163 34 ± 79 4.234 <0.001 101
AHP (mV) 18 ± 10 24 ± 7 -3.576 <0.001 101
First AP threshold (mV) 42 ± 4 40 ± 3 2.839 0.006 101
Membrane tau (ms) 44 ± 18 52 ± 16 -2.268 0.025 101
RMP (mV) 58.9 ± 9.3 60.6 ± 7.0 -0.929 >0.05 101
Rin (MΩ) 610 ± 301 641 ± 247 -0.512 >0.05 101
First AP amplitude (mV) 71 ± 9 72 ± 7 -0.395 >0.05 101
First AP half-width (ms) 1.8 ± 0.5 1.8 ± 0.4 0.160 >0.05 101

Ranked in order of highest-to-lowest significant difference. Differences tested using the t-Student test for independent measures.
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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Basalis nucleus cholinergic neuron Basal forebrain ChAT-expressing early-firing neurons FI slope (Hz/pA) 0.06 ± 0.04 (70) 60.0 (Hz/nA) Data Table
Basalis nucleus cholinergic neuron Basal forebrain ChAT-expressing late-firing neurons FI slope (Hz/pA) 0.03 ± 0.02 (33) 30.0 (Hz/nA) Data Table
Basalis nucleus cholinergic neuron Basal forebrain ChAT-expressing early-firing neurons first spike latency (ms) 107.0 ± 53.0 (70) 107.0 (ms) Data Table
Basalis nucleus cholinergic neuron Basal forebrain ChAT-expressing early-firing neurons adaptation ratio (last/first ISI) 2.74 ± 2.57 (70) 2.74 (ratio) Data Table
Basalis nucleus cholinergic neuron Basal forebrain ChAT-expressing late-firing neurons adaptation ratio (last/first ISI) 1.33 ± 0.57 (33) 1.33 (ratio) Data Table
Basalis nucleus cholinergic neuron Basal forebrain ChAT-expressing late-firing neurons first spike latency (ms) 343.0 ± 76.0 (33) 343.0 (ms) Data Table
Basalis nucleus cholinergic neuron Basal forebrain ChAT-expressing early-firing neurons AHP amplitude (mV) 18.0 ± 10.0 (70) 18.0 (mV) Data Table
Basalis nucleus cholinergic neuron Basal forebrain ChAT-expressing late-firing neurons AHP amplitude (mV) 24.0 ± 7.0 (33) 24.0 (mV) Data Table
Basalis nucleus cholinergic neuron Basal forebrain ChAT-expressing early-firing neurons spike threshold (mV) 42.0 ± 4.0 (70) -42.0 (mV) Data Table
Basalis nucleus cholinergic neuron Basal forebrain ChAT-expressing late-firing neurons spike threshold (mV) 40.0 ± 3.0 (33) -40.0 (mV) Data Table
Basalis nucleus cholinergic neuron Basal forebrain ChAT-expressing early-firing neurons membrane time constant (ms) 44.0 ± 18.0 (70) 44.0 (ms) Data Table
Basalis nucleus cholinergic neuron Basal forebrain ChAT-expressing late-firing neurons membrane time constant (ms) 52.0 ± 16.0 (33) 52.0 (ms) Data Table
Basalis nucleus cholinergic neuron Basal forebrain ChAT-expressing early-firing neurons resting membrane potential (mV) 58.9 ± 9.3 (70) -58.9 (mV) Data Table
Basalis nucleus cholinergic neuron Basal forebrain ChAT-expressing late-firing neurons resting membrane potential (mV) 60.6 ± 7.0 (33) -60.6 (mV) Data Table
Basalis nucleus cholinergic neuron Basal forebrain ChAT-expressing early-firing neurons input resistance (MΩ) 610.0 ± 301.0 (70) 610.0 (MΩ) Data Table
Basalis nucleus cholinergic neuron Basal forebrain ChAT-expressing late-firing neurons input resistance (MΩ) 641.0 ± 247.0 (33) 641.0 (MΩ) Data Table
Basalis nucleus cholinergic neuron Basal forebrain ChAT-expressing early-firing neurons spike amplitude (mV) 71.0 ± 9.0 (70) 71.0 (mV) Data Table
Basalis nucleus cholinergic neuron Basal forebrain ChAT-expressing late-firing neurons spike amplitude (mV) 72.0 ± 7.0 (33) 72.0 (mV) Data Table
Basalis nucleus cholinergic neuron Basal forebrain ChAT-expressing early-firing neurons spike half-width (ms) 1.8 ± 0.5 (70) 1.8 (ms) Data Table
Basalis nucleus cholinergic neuron Basal forebrain ChAT-expressing late-firing neurons spike half-width (ms) 1.8 ± 0.4 (33) 1.8 (ms) Data Table