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Article: Ex vivo dissection of optogenetically activated mPFC and hippocampal inputs to neurons in the basolateral amygdala: implications for fear and emotional memory.

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Hübner C; Bosch D; Gall A; Lüthi A; Ehrlich I
Front Behav Neurosci, 2014


Properties of recorded principal neurons.

Input type mPFC vHC Statistical comparisons
Cell type all PN (n = 65) uPN (n = 21) bPN (n = 26) plPN (n = 22) all PN (n = 45) uPN (n = 14) bPN (n = 24) plPN (n = 10) ilPN (n = 11)
Vrest (mV) -69.35±0.72 -70.24±0.85 -69.38±1.22 -69.68±1.18 -67.31±0.88 -64.43±1.951 -68.63±1.051 -70±1.71 -67±1.58 1p < 0.05
Rinput (MOhm) 169.14±11.67 154.81±16.23 181.39±23.82 173.33±24.89 155±7.69 136.34±7.57 162.25±12.25 177.63±18.11 161.91±19.66
Rseries (MOhm) 20.8±0.58 20.62±1.45 18.83±0.9 18.75±1.06 21.58±0.93 23.52±2.13 19.92±1.05 20.17±1.99 19.98±1.51
Membrane tau (ms) 3.62±0.16 3.97±0.36 3.34±0.21 3.37±0.23 3.47±0.24 3.93±0.6 3.37±0.26 3.71±0.5 3.14±0.32
Capacitance (nF) 202.6±5.77 219.30±8.34 201.12±9.54 204.48±10.37 184.01±8.24 188.58±17.37 193.25±10.3 207.76±17.52 180.16±13.72
Excitability (Hz) 14.46±1.16 11.52±1.92 12.62±1.71 11.55±1.8 15.07±1.07 11.714±1.48 15.33±1.41 16±2.21 15.27±2.32
Spike threshold (mV) -38.50±0.56 -36.81±0.8 -38.81±0.92 -39.02±1.06 -38±0.6 -38.47±0.93 -37.35±0.98 -38.29±1.37 -35.84±1.69
Spike amplitude (mV) 81.15±0.88 82.15±1.04 83.59±0.87 83.44±0.92 82.03±1.15 82.14±2.5 82.23±1.48 80.55±2.71 82.89±2.08
Spike half-width (ms) 1.16±0.011 1.15±0.03 1.16±0.02 1.16±0.02 1.23±0.031 1.32±0.07 1.2±0.03 1.22±0.05 1.181±PM 1p < 0.05
fAHP (mV) -4.77±0.3 -4.72±0.47 -4.84±0.44 -4.63±0.51 -4.49±0.36 -3.26±0.61 -5.28±0.511 -5.75±0.78 -5.52±0.78 1p < 0.05

Excitability (Hz), spike frequency at 200 pA current injection; fAHP, fast afterhyperpolarization; all PN, all recorded principal neurons; uPN, unlabeled principal neuron; bPN, mPFCbackprojecting principal neuron; plPN, principal neuron projecting to prelimbic cortex; ilPN, principal neuron projecting to infralimbic cortex; values represent mean ± s.e.m. (n, number of recorded cells); statistical comparisons: superscript numbers represent pairs of significantly different values.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Amygdala basolateral nucleus pyramidal neuron Basolateral amygdala principal neuron with input from medial prefrontal cortex fast AHP amplitude (mV) -4.77 ± 0.3 (65) 4.77 (mV) Data Table
Amygdala basolateral nucleus pyramidal neuron Basolateral amygdala principal neurons with input from ventral hippocampus fast AHP amplitude (mV) -4.49 ± 0.36 (45) 4.49 (mV) Data Table
Amygdala basolateral nucleus pyramidal neuron Basolateral amygdala principal neuron with input from medial prefrontal cortex input resistance 169.14 ± 11.67 (65) 169.14 (MΩ) Data Table
Amygdala basolateral nucleus pyramidal neuron Basolateral amygdala principal neurons with input from ventral hippocampus input resistance 155.0 ± 7.69 (45) 155.0 (MΩ) Data Table
Amygdala basolateral nucleus pyramidal neuron Basolateral amygdala principal neuron with input from medial prefrontal cortex resting membrane potential (mV) -69.35 ± 0.72 (65) -69.35 (mV) Data Table
Amygdala basolateral nucleus pyramidal neuron Basolateral amygdala principal neuron with input from medial prefrontal cortex access resistance 20.8 ± 0.58 (65) 20.8 (MΩ) Data Table
Amygdala basolateral nucleus pyramidal neuron Basolateral amygdala principal neurons with input from ventral hippocampus access resistance 21.58 ± 0.93 (45) 21.58 (MΩ) Data Table
Amygdala basolateral nucleus pyramidal neuron Basolateral amygdala principal neuron with input from medial prefrontal cortex membrane time constant (ms) 3.62 ± 0.16 (65) 3.62 (ms) Data Table
Amygdala basolateral nucleus pyramidal neuron Basolateral amygdala principal neurons with input from ventral hippocampus membrane time constant (ms) 3.47 ± 0.24 (45) 3.47 (ms) Data Table
Amygdala basolateral nucleus pyramidal neuron Basolateral amygdala principal neuron with input from medial prefrontal cortex cell capacitance (nF) 202.6 ± 5.77 (65) -- Data Table
Amygdala basolateral nucleus pyramidal neuron Basolateral amygdala principal neurons with input from ventral hippocampus cell capacitance (nF) 184.01 ± 8.24 (45) -- Data Table
Amygdala basolateral nucleus pyramidal neuron Basolateral amygdala principal neuron with input from medial prefrontal cortex other (Hz) 14.46 ± 1.16 (65) -- Data Table
Amygdala basolateral nucleus pyramidal neuron Basolateral amygdala principal neurons with input from ventral hippocampus resting membrane potential (mV) -67.31 ± 0.88 (45) -67.31 (mV) Data Table
Amygdala basolateral nucleus pyramidal neuron Basolateral amygdala principal neurons with input from ventral hippocampus other (Hz) 15.07 ± 1.07 (45) -- Data Table
Amygdala basolateral nucleus pyramidal neuron Basolateral amygdala principal neuron with input from medial prefrontal cortex spike threshold (mV) -38.5 ± 0.56 (65) -38.5 (mV) Data Table
Amygdala basolateral nucleus pyramidal neuron Basolateral amygdala principal neurons with input from ventral hippocampus spike threshold (mV) -38.0 ± 0.6 (45) -38.0 (mV) Data Table
Amygdala basolateral nucleus pyramidal neuron Basolateral amygdala principal neuron with input from medial prefrontal cortex spike amplitude (mV) 81.15 ± 0.88 (65) 81.15 (mV) Data Table
Amygdala basolateral nucleus pyramidal neuron Basolateral amygdala principal neurons with input from ventral hippocampus spike amplitude (mV) 82.03 ± 1.15 (45) 82.03 (mV) Data Table
Amygdala basolateral nucleus pyramidal neuron Basolateral amygdala principal neuron with input from medial prefrontal cortex spike half-width (ms) 1.16 ± 0.011 (65) 1.16 (ms) Data Table
Amygdala basolateral nucleus pyramidal neuron Basolateral amygdala principal neurons with input from ventral hippocampus spike half-width (ms) 1.23 ± 0.031 (45) 1.23 (ms) Data Table