Article: Ex vivo dissection of optogenetically activated mPFC and hippocampal inputs to neurons in the basolateral amygdala: implications for fear and emotional memory.
Properties of EPSCs onto principal neurons by specific input and output.
Input type
mPFC
vHC
Statistical comparisons
PL
IL
PL
Cell type
PN
PN
plPN
plPN
ilPN
Amplitude (pA)
-457.9±40.56 (33)
-316.25±64.52 (11)
-463.66±57.49 (17)1
-292.19±45.51 (10)1
-186.46±46.34 (10)
1p < 0.05
Latency (ms)
2.96±0.15 (33)
2.84±0.17 (11)
3.29±0.25 (17)1
2.46±0.17 (10)1
2.3±0.16 (10)
1p < 0.05
Rise time (ms)
2.73±0.11 (33)
3.16±0.22 (11)
2.82±0.2 (17)
2.25±0.2 (10)
2.12±0.27 (10)
Decay time (ms)
8.71±0.44 (33)1
11.22±1.02 (11)1
8.91±0.74 (17)2
6.58±0.58 (10)2
8.01±1.17 (10)
1,2p < 0.05
PPR 50 ms
1.29±0.24 (28)
0.9±0.2 (8)
1.67±0.5 (13)
0.54±0.1 (10)
0.56±0.1 (10)
PPR 100 ms
1.55±0.19 (28)
1.23±0.11 (9)
1.83±0.4 (13)
1.03±0.09 (10)
1.22±0.09 (10)
PPR 300 ms
1.11±0.03 (28)
1.05±0.11 (6)
1.07±0.03 (13)
1.0±0.06 (10)
1.0±0.06 (10)
I/E ratio
0.27±0.08 (23)
0.18±0.7 (6)
0.24±0.08 (11)
0.47±0.27 (9)
0.62±0.37 (6)
PPR, paired-pulse ratio; I/E ratio, inhibition-to-excitation ratio; PN, principal neuron; PL, prelimbic cortex; IL, infralimbic cortex; plPN, principal neuron projecting to prelimbic cortex; ilPN, principal neuron projecting to infralimbic cortex; values represent mean ± s.e.m. (n, number of recorded cells); comparisons: superscript numbers represent pairs of significantly different values.
