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Article: Competition from newborn granule cells does not drive axonal retraction of silenced old granule cells in the adult hippocampus.

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Lopez CM; Pelkey KA; Chittajallu R; Nakashiba T; Tóth K; Tonegawa S; McBain CJ
Front Neural Circuits, 2012


Summary of electrophysiological properties of mature granule cells.

Control mice DG-TeTX mice
Intrinsic membrane properties (n = 14 cells from 5 mice) (n = 15 cells from 4 mice)
Resting potential (mV) -71 ± 1 -68 ± 2
Input resistance (MΩ) 199 ± 14 225 ± 27
Time constant (ms) 23 ± 2 19 ± 2
Membrane capacitance (pF) 117 ± 9 94 ± 8
Frequency at 2× threshold (Hz) 23 ± 2 19 ± 2
Spike threshold (mV) -35 ± 2 -35 ± 2
Spike amplitude (mV) 77 ± 3 74 ± 3
Spike half-width (ms) 0.84 ± 0.04 0.87 ± 0.06
Spike maximal decay (mV/ms) -93 ± 5 -90 ± 6
IPSC properties (n = 8 cells from 3 mice) (n = 3 cells from 2 mice)
sIPSC amplitude (pA) -60 ± 5 -64 ± 14
sIPSC frequency (Hz) 5 ± 0.4 4.3 ± 1.1
sIPSC τdecay (ms) 7.6 ± 0.4 8.2 ± 0.5
GABAtonic (pA) -30 ± 8 -45 ± 19
EPSC properties (n = 6 cells s/eEPSCs, 5 cells LTP from 3 mice) (n = 6 cells s/eEPSCs, 6 cells LTP from 4 mice)
sEPSC amplitude (pA) -11 ± 1 -10 ± 0.6
sEPSC frequency (Hz) 1.6 ± 0.3 1.3 ± 0.2
sEPSC τdecay (ms) 5.6 ± 0.5 5.8 ± 0.3
eEPSC AMPA/NMDA ratio 1.3 ± 0.2 1.5 ± 0.2
eEPSC PPR 1.0 ± 0.04 1.2 ± 0.09
eEPSCNMDA τdecay (ms) 73 ± 3 83 ± 7
eEPSC TBS LTP (% control) 212 ± 47 191 ± 50

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Dentate gyrus granule cell cell capacitance (pF) 117.0 ± 9.0 (14) 117.0 (pF) Data Table
Dentate gyrus granule cell spike threshold (mV) -35.0 ± 2.0 (14) -35.0 (mV) Data Table
Dentate gyrus granule cell resting membrane potential (mV) -71.0 ± 1.0 (14) -71.0 (mV) Data Table
Dentate gyrus granule cell spike amplitude (mV) 77.0 ± 3.0 (14) 77.0 (mV) Data Table
Dentate gyrus granule cell spike half-width (ms) 0.84 ± 0.04 (14) 0.84 (ms) Data Table
Dentate gyrus granule cell spike max decay slope (mV/ms) -93.0 ± 5.0 (14) 93.0 (mV/ms) Data Table
Dentate gyrus granule cell input resistance (MΩ) 199.0 ± 14.0 (14) 199.0 (MΩ) Data Table
Dentate gyrus granule cell membrane time constant (ms) 23.0 ± 2.0 (14) 23.0 (ms) Data Table