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Article: Tonotopic organization of the hyperpolarization-activated current (Ih) in the mammalian medial superior olive.

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Baumann VJ; Lehnert S; Leibold C; Koch U
Front Neural Circuits, 2013


Summary of HCN channel properties, membrane properties and synaptic properties of dorsal and ventral neurons for P18 and P22.

P18 P22
Ventral Dorsal P Ventral Dorsal P
HCN CHANNEL PROPERTIES (AT -110.5 mV)
Current [pA] -3006 ± 165 (15) -1909 ± 277 (18) ** -3303 ± 134 (8) -2559 ± 238 (9) *
Current density [pA/pF] -127.7 ± 5.3 (15) -73.4 ± 9.3 (18) *** 122.4 ± 4.9 (6) 92.7 ± 5.0 (9) *
Half-maximal activation voltage [mV] -79 ± 1 (15) -87 ± 2 (18) ** -76 ± 3 (8) -81 ± 2 (9) n.s.
τweighted [ms] 95.6 ± 7.0 (15) 191.3 ± 28.1 (18) ** 78.0 ± 3.6 (8) 109.6 ± 18.7 (9) n.s.
MEMBRANE PROPERTIES (AT -100 pA)
Resting potential [mV] -58.8 ± 0.3 (24) -59.1 ± 0.6 (35) n.s. -60.0 ± 0.7 (10) -60.1 ± 0.9 (12) n.s.
Input resistance [MΩ] 10.7 ± 1.8 (24) 18.9 ± 5.5 (35) n.s. 3.7 ± 7.0 (10) 24.0 ± 6.4 (12) *
Membrane time constant [ms] 0.69 ± 0.09 (24) 1.23 ± 0.27 (35) n.s. 0.45 ± 0.07 (10) 1.64 ± 0.45 (12) *
SYNAPTIC PROPERTIES
IPSP half-width [ms] 3.76 ± 0.25 (13) 5.63 ± 0.60 (10) ** 2.72 ± 0.06 (10) 4.29 ± 0.51 (13) *
Rise time 10–90% [ms] 1.10 ± 0.01 (13) 1.12 ± 0.03 (10) n.s. 1.14 ± 0.03 (10) 1.37 ± 0.07 (13) *
Decay time 90–10% [ms] 2.51 ± 0.16 (13) 4.05 ± 0.56 (10) ** 1.84 ± 0.08 (10) 3.08 ± 0.39 (13) **

Values are mean ± SEM. The level of significance between ventral and dorsal was determined by using Student's unpaired t-test except for HCN channel properties of P18, where Scheffe's post-hoc test was employed following a single-factor ANOVA test (

P < 0.05,

P < 0.01,

P < 0.001,

n.s. not significant). The n-values for each group are stated in brackets.
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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other Medial superior Olive Ventral cell resting membrane potential -58.8 ± 0.3 (24) -58.8 (mV) Data Table
Other Medial superior olive dorsal cell resting membrane potential -59.1 ± 0.6 (35) -59.1 (mV) Data Table
Other Medial superior olive ventral cell resting membrane potential -60.0 ± 0.7 (10) -60.0 (mV) Data Table
Other Medial superior olive dorsal cell resting membrane potential -60.1 ± 0.9 (12) -60.1 (mV) Data Table
Other Medial superior Olive Ventral cell input resistance 10.7 ± 1.8 (24) 10.7 (MΩ) Data Table
Other Medial superior olive dorsal cell input resistance 18.9 ± 5.5 (35) 18.9 (MΩ) Data Table
Other Medial superior olive ventral cell input resistance 3.7 ± 7.0 (10) -- Data Table
Other Medial superior olive dorsal cell input resistance 24.0 ± 6.4 (12) 24.0 (MΩ) Data Table
Other Medial superior Olive Ventral cell membrane time constant 0.69 ± 0.09 (24) 0.69 (ms) Data Table
Other Medial superior olive dorsal cell membrane time constant 1.23 ± 0.27 (35) 1.23 (ms) Data Table
Other Medial superior olive ventral cell membrane time constant 0.45 ± 0.07 (10) 0.45 (ms) Data Table
Other Medial superior olive dorsal cell membrane time constant 1.64 ± 0.45 (12) 1.64 (ms) Data Table