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Article: Diversity and overlap of parvalbumin and somatostatin expressing interneurons in mouse presubiculum.

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Nassar M; Simonnet J; Lofredi R; Cohen I; Savary E; Yanagawa Y; Miles R; Fricker D
Front Neural Circuits, 2015


Electrophysiological parameters (mean ± SEM) of presubicular pyramidal cells (PC, n = 17) and interneurons recorded from the three mouse lines (X98 GFP, 35; Sst-Cre tdTomato, 61; Pvalb-Cre tdTomato, 46). Using these parameters for Ward’s unsupervised cluster analysis permitted separation of clusters 0, 1, 2, and 3. Values (mean ± SEM) for each parameter are given for each cluster in (B).

PC
X98 GFP
Sst Cre tdTomato
Pvalb Cre tdTomato
Mean SEM n Mean SEM n Mean SEM n Mean SEM n
(A)
RMP (mV) -78 1 17 -54 1 35 -58 1 61 -65 1 46
Rin (MΩ) 250 24 17 376 22 35 285 20 61 148 9 46
Time constant (ms) 28 4 17 36 3 35 21 2 61 10 1 46
Sag 1.04 0.00 17 1.25 0.02 35 1.15 0.01 61 1.10 0.01 46
Rheobase (pA) 84 9 17 40 4 35 72 9 61 175 14 46
I-O gain (Hz/nA; MeanInsF) 275 23 17 748 38 35 917 54 61 1015 92 46
I-O gain (Hz/nA; APs/sec) 270 22 17 732 46 35 885 59 61 1065 98 46
MeanInsF (Hz) 33 3 17 33 3 35 74 8 61 247 19 46
Coefficient of variation 0.21 0.02 17 0.28 0.03 35 0.15 0.01 61 0.06 0.00 46
Latency (ms) 27 3 17 21 2 35 15 1 61 13 2 46
Adaptation Index 0.72 0.04 17 0.66 0.02 35 0.86 0.02 61 0.94 0.02 46
Threshold (mV) -35.5 0.5 17 -38.2 0.4 35 -38.5 0.5 61 -39.6 0.6 46
Width (ms) 0.56 0.02 17 0.27 0.01 35 0.27 0.01 61 0.20 0.01 46
Amplitude (pA) 84 2 17 83 1 35 77 1 61 72 1 46
AHP (mV) -14.7 0.6 17 -23.8 0.7 35 -23.5 0.5 61 -23.7 0.6 46
Max depol. rate (V.s-1) 517 22 17 598 14 35 571 13 61 637 18 46
Min depol. rate (V.s-1) -134 6 17 -355 11 35 -353 14 61 -498 22 46

Cluster 0
Cluster 1
Cluster 2
Cluster 3
Mean SEM n Mean SEM n Mean SEM n Mean SEM n

(B)
RMP (mV) -78 1 17 -54 1 65 -60 1 48 -70 1 29
Rin (MΩ) 250 24 17 374 17 65 189 11 48 137 17 29
Time constant (ms) 28 4 17 32 2 65 11 1 48 13 2 29
Sag 1.04 0.00 17 1.22 0.01 65 1.11 0.01 48 1.09 0.01 29
Rheobase (pA) 84 9 17 40 3 65 113 8 48 202 23 29
I–O gain (Hz/nA; MeanInsF) 275 23 17 778 28 65 762 41 48 1437 131 29
I–O gain (Hz/nA; APs/sec) 270 22 17 746 35 65 747 43 48 1525 132 29
MeanInsF (Hz) 33 3 17 35 2 65 128 7 48 297 27 29
Coefficient of variation 0.21 0.02 17 0.24 0.02 65 0.07 0.00 48 0.08 0.02 29
Latency (ms) 27 3 17 21 1 65 14 2 48 8 2 29
Adaptation Index 0.72 0.04 17 0.70 0.01 65 0.92 0.02 48 1.00 0.02 29
Threshold (mV) -35.5 0.5 17 -38.4 0.4 65 -37.4 0.5 48 -42.2 0.7 29
Width (ms) 0.56 0.02 17 0.29 0.01 65 0.23 0.00 48 0.18 0.01 29
Amplitude (pA) 84 2 17 82 1 65 76 1 48 69 2 29
AHP (mV) -14.7 0.6 17 -23.8 0.5 65 -23.8 0.5 48 -22.9 0.8 29
Maximum depolarization rate (V.s-1) 517 22 17 567 11 65 627 14 48 623 26 29
Minimum depolarization rate (V.s-1) -134 6 17 -329 9 65 -409 15 48 -547 30 29

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex interneuron deep Presubiculum somatostatin-expressing interneuron maximum firing rate (Hz) 74.0 (61) 74.0 (Hz) Data Table
Neocortex interneuron deep Presubiculum parvalbumin interneuron maximum firing rate (Hz) 247.0 (46) 247.0 (Hz) Data Table
Neocortex interneuron deep Presubiculum parvalbumin interneuron resting membrane potential (mV) -65.0 (46) -65.0 (mV) Data Table
Subiculum pyramidal cell Presubicular pyramidal cells first spike latency (ms) 27.0 (17) 27.0 (ms) Data Table
Neocortex interneuron deep Presubiculum somatostatin-expressing interneuron first spike latency (ms) 21.0 (35) 21.0 (ms) Data Table
Neocortex interneuron deep Presubiculum somatostatin-expressing interneuron first spike latency (ms) 15.0 (61) 15.0 (ms) Data Table
Neocortex interneuron deep Presubiculum parvalbumin interneuron first spike latency (ms) 13.0 (46) 13.0 (ms) Data Table
Subiculum pyramidal cell Presubicular pyramidal cells adaptation ratio 0.72 (17) 0.72 (ratio) Data Table
Neocortex interneuron deep Presubiculum somatostatin-expressing interneuron adaptation ratio 0.66 (35) 0.66 (ratio) Data Table
Neocortex interneuron deep Presubiculum somatostatin-expressing interneuron adaptation ratio 0.86 (61) 0.86 (ratio) Data Table
Neocortex interneuron deep Presubiculum parvalbumin interneuron adaptation ratio 0.94 (46) 0.94 (ratio) Data Table
Subiculum pyramidal cell Presubicular pyramidal cells spike threshold (mV) -35.5 (17) -35.5 (mV) Data Table
Neocortex interneuron deep Presubiculum somatostatin-expressing interneuron spike threshold (mV) -38.2 (35) -38.2 (mV) Data Table
Neocortex interneuron deep Presubiculum somatostatin-expressing interneuron spike threshold (mV) -38.5 (61) -38.5 (mV) Data Table
Neocortex interneuron deep Presubiculum parvalbumin interneuron spike threshold (mV) -39.6 (46) -39.6 (mV) Data Table
Subiculum pyramidal cell Presubicular pyramidal cells spike half-width (ms) 0.56 (17) 0.56 (ms) Data Table
Subiculum pyramidal cell Presubicular pyramidal cells input resistance (MΩ) 250.0 (17) 250.0 (MΩ) Data Table
Neocortex interneuron deep Presubiculum somatostatin-expressing interneuron spike half-width (ms) 0.27 (35) 0.27 (ms) Data Table
Neocortex interneuron deep Presubiculum somatostatin-expressing interneuron spike half-width (ms) 0.27 (61) 0.27 (ms) Data Table
Neocortex interneuron deep Presubiculum parvalbumin interneuron spike half-width (ms) 0.2 (46) 0.2 (ms) Data Table
Subiculum pyramidal cell Presubicular pyramidal cells AHP amplitude (mV) -14.7 (17) 14.7 (mV) Data Table
Neocortex interneuron deep Presubiculum somatostatin-expressing interneuron AHP amplitude (mV) -23.8 (35) 23.8 (mV) Data Table
Neocortex interneuron deep Presubiculum somatostatin-expressing interneuron input resistance (MΩ) 376.0 (35) 376.0 (MΩ) Data Table
Neocortex interneuron deep Presubiculum somatostatin-expressing interneuron AHP amplitude (mV) -23.5 (61) 23.5 (mV) Data Table
Neocortex interneuron deep Presubiculum parvalbumin interneuron AHP amplitude (mV) -23.7 (46) 23.7 (mV) Data Table
Subiculum pyramidal cell Presubicular pyramidal cells spike max rise slope 517.0 (17) 517.0 (mV/ms) Data Table
Neocortex interneuron deep Presubiculum somatostatin-expressing interneuron spike max rise slope 598.0 (35) 598.0 (mV/ms) Data Table
Neocortex interneuron deep Presubiculum somatostatin-expressing interneuron spike max rise slope 571.0 (61) 571.0 (mV/ms) Data Table
Neocortex interneuron deep Presubiculum parvalbumin interneuron spike max rise slope 637.0 (46) 637.0 (mV/ms) Data Table
Subiculum pyramidal cell Presubicular pyramidal cells spike max decay slope -134.0 (17) 134.0 (mV/ms) Data Table
Neocortex interneuron deep Presubiculum somatostatin-expressing interneuron spike max decay slope -355.0 (35) 355.0 (mV/ms) Data Table
Neocortex interneuron deep Presubiculum somatostatin-expressing interneuron spike max decay slope -353.0 (61) 353.0 (mV/ms) Data Table
Neocortex interneuron deep Presubiculum somatostatin-expressing interneuron input resistance (MΩ) 285.0 (61) 285.0 (MΩ) Data Table
Neocortex interneuron deep Presubiculum parvalbumin interneuron spike max decay slope -498.0 (46) 498.0 (mV/ms) Data Table
Neocortex interneuron deep Presubiculum parvalbumin interneuron input resistance (MΩ) 148.0 (46) 148.0 (MΩ) Data Table
Subiculum pyramidal cell Presubicular pyramidal cells membrane time constant (ms) 28.0 (17) 28.0 (ms) Data Table
Subiculum pyramidal cell Presubicular pyramidal cells resting membrane potential (mV) -78.0 (17) -78.0 (mV) Data Table
Neocortex interneuron deep Presubiculum somatostatin-expressing interneuron membrane time constant (ms) 36.0 (35) 36.0 (ms) Data Table
Neocortex interneuron deep Presubiculum somatostatin-expressing interneuron membrane time constant (ms) 21.0 (61) 21.0 (ms) Data Table
Neocortex interneuron deep Presubiculum parvalbumin interneuron membrane time constant (ms) 10.0 (46) 10.0 (ms) Data Table
Subiculum pyramidal cell Presubicular pyramidal cells sag ratio 1.04 (17) 1.04 (ratio) Data Table
Neocortex interneuron deep Presubiculum somatostatin-expressing interneuron sag ratio 1.25 (35) 1.25 (ratio) Data Table
Neocortex interneuron deep Presubiculum somatostatin-expressing interneuron sag ratio 1.15 (61) 1.15 (ratio) Data Table
Neocortex interneuron deep Presubiculum parvalbumin interneuron sag ratio 1.1 (46) 1.1 (ratio) Data Table
Subiculum pyramidal cell Presubicular pyramidal cells rheobase (pA) 84.0 (17) 84.0 (pA) Data Table
Neocortex interneuron deep Presubiculum somatostatin-expressing interneuron rheobase (pA) 40.0 (35) 40.0 (pA) Data Table
Neocortex interneuron deep Presubiculum somatostatin-expressing interneuron resting membrane potential (mV) -54.0 (35) -54.0 (mV) Data Table
Neocortex interneuron deep Presubiculum somatostatin-expressing interneuron rheobase (pA) 72.0 (61) 72.0 (pA) Data Table
Neocortex interneuron deep Presubiculum parvalbumin interneuron rheobase (pA) 175.0 (46) 175.0 (pA) Data Table
Subiculum pyramidal cell Presubicular pyramidal cells FI slope 270.0 (17) 270.0 (Hz/nA) Data Table
Neocortex interneuron deep Presubiculum somatostatin-expressing interneuron FI slope 732.0 (35) 732.0 (Hz/nA) Data Table
Neocortex interneuron deep Presubiculum somatostatin-expressing interneuron FI slope 885.0 (61) 885.0 (Hz/nA) Data Table
Neocortex interneuron deep Presubiculum somatostatin-expressing interneuron resting membrane potential (mV) -58.0 (61) -58.0 (mV) Data Table
Neocortex interneuron deep Presubiculum parvalbumin interneuron FI slope 1065.0 (46) 1065.0 (Hz/nA) Data Table
Subiculum pyramidal cell Presubicular pyramidal cells maximum firing rate (Hz) 33.0 (17) 33.0 (Hz) Data Table
Neocortex interneuron deep Presubiculum somatostatin-expressing interneuron maximum firing rate (Hz) 33.0 (35) 33.0 (Hz) Data Table