Article: Reduced inhibition of dentate granule cells in a model of temporal lobe epilepsy.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Kobayashi M; Buckmaster PS J. Neurosci., 2003
Adult control | Epileptic | Young control | 3–7 d post-status | |
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Number of cells | 12 | 16 | 15 | 30 |
Fast-rising mIPSCs | ||||
10–90% rise time (msec) | 0.89 ± 0.06 | 0.86 ± 0.05 | 0.93 ± 0.07 | 0.84 ± 0.04 |
Proportion | 0.29 ± 0.03 | 0.30 ± 0.01 | 0.27 ± 0.02 | 0.33 ± 0.03 |
Amplitude (pA) | 10.9 ± 1.12-159 | 19.8 ± 3.72-167,* | 10.7 ± 0.92-159 | 17.1 ± 1.32-159,2-160 |
Slow-rising mIPSCs | ||||
10–90% rise time (msec) | 2.11 ± 0.08 | 2.17 ± 0.11 | 2.02 ± 0.14 | 2.05 ± 0.09 |
Proportion | 0.71 ± 0.03 | 0.70 ± 0.01 | 0.73 ± 0.02 | 0.67 ± 0.03 |
Amplitude (pA) | 8.8 ± 0.7 | 9.9 ± 0.5 | 9.2 ± 0.7 | 11.3 ± 0.6* |
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Histograms of mIPSC rise times from individual cells were fit with two Gaussian curves (Fig. 8 e). From the two Gaussian curves, the average rise times of fast-rising and slow-rising events were calculated. Those results were compiled for cells from animals in all four experimental groups, and the values in this Table represent the means ± SEM. There were no significant differences in the average rise times or proportion of fast- versus slow-rising events between epileptic, 3–7 d post-status epilepticus, and control rats (t test). Average amplitudes of the fastest fast-rising (10–90% rise time less than the median minus 1 SD) and the slowest slow-rising (10–90% rise time more than the median plus 1 SD) were calculated and are shown in this Table. Within each experimental group, the average amplitudes of the fastest fast-rising mIPSCs were larger than the average amplitudes of the slowest slow-rising mIPSCs (
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↵F2-159 p < 0.05;
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↵F2-167 p < 0.001; paired ttest). The average amplitude of the fastest fast-rising mIPSCs in epileptic rats was 182% of that of adult controls (
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↵* p < 0.05; unpaired t test). Similarly, the average amplitude of the fastest fast-rising mIPSCs in 3–7 d post-status epilepticus rats was 160% of that of young controls (
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↵F2-160 p < 0.001; unpaired t test). The average amplitude of the slowest slow-rising mIPSCs in 3–7 d post-status epilepticus rats was 123% of that of young controls (*p < 0.05; unpaired ttest).
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
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