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Article: Inter- and intralaminar subcircuits of excitatory and inhibitory neurons in layer 6a of the rat barrel cortex.

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Kumar P; Ohana O
J. Neurophysiol., 2008



TABLE 2.Physiological parameters of CT, CC1, and CC2 pyramidal neurons
Physiological Parameters CT (34) CC (38) P Value ROC Area CC1 (6) CC2 (11) P Value ROC Area
RMP, mV –70.2 +/– 3.6 –70.5 +/– 4.5 0.76 –71.0 +/– 3.4 –70.6 +/– 4.9 0.86
Input resistance, MΩ 146.2 +/– 47.0 152.1 +/– 56.2 0.63 133.3 +/– 32.4 154.0 +/– 38.9 0.26
Membrane tau, ms 12.0 +/– 2.7 16.5 +/– 4.0 6.5E-07 0.84 18.1 +/– 3.4 16.4 +/– 3.7 0.33
Rheobase, pA 195.6 +/– 79.8 133.4 +/– 56.5 6.3E-04 0.77
AP1 amplitude, mV 101.7 +/– 6.7 102.0 +/– 8.8 0.89
AP1 latency, ms 67.9 +/– 22.1 137.1 +/– 50.6 7.9E-10 0.92
AP1 half-width, ms 0.77 +/– 0.12 1.02 +/– 0.16 1.2E-09 0.88 0.85 +/– 0.15 1.08 +/– 0.17 7.4E-0.3 0.84
AP1 rise slope, mV/ms 99.3 +/– 18.5 105.1 +/– 22.6 0.24 106.3 +/– 27.0 107.8 +/– 17.4 0.88
AP1 fall slope, mV/ms –79.1 +/– 13.8 –50.7 +/– 13.2 3.6E-13 0.93 –68.3 +/– 9.4 –45.1 +/– 9.9 7.7E05 0.94
AP1 threshold-absolute, mV –30.4 +/– 5.0 –32.2 +/– 4.7 2.4E-02 0.62
AP1 threshold-relative, mV 40.0 +/– 4.4 38.3 +/– 4.5 0.10
AP1 fAHP amplitude, mV –13.7 +/– 3.4 –9.4 +/– 4.2 1.1E-05 0.78
AP1 sAHP amplitude, mV –17.1 +/– 2.9 –15.5 +/– 4.5 0.74
AP1 fAHP latency, ms 4.4 +/– 3.4 9.0 +/– 5.3 4.8E-07 0.82
AP1 sAHP latency, ms 17.6 +/– 7.6 63.7 +/– 26.3 7.3E-15 0.93
Max avg frequency, Hz 39.0 +/– 14.8 48.9 +/– 12.8 0.08 51.6 +/– 17.7 46.2 +/– 10.0 0.42
Max 1st inst. frequency, Hz 142.1 +/– 57.4 223.8 +/– 59.6 1.5E-06 0.83 268.7 +/– 47.1 198.2 +/– 64.6 4.2E-02 0.82
Max 2nd inst. frequency, Hz 74.1 +/– 35.9 121.0 +/– 59.2 3.9E-03 0.75 169.5 +/– 63.2 95.8 +/– 48.0 1.6E-02 0.83
2xRheobase: Avg. freq., Hz 28.4 +/– 6.1 25.0 +/– 6.4 3.1E-02 0.70 24.3 +/– 4.0 24.7 +/– 4.8 0.86
2xRheobase: 1st inst. freq., Hz 61.7 +/– 24.3 140.1 +/– 69.6 2.3E-05 0.87 224.5 +/– 39.9 108.8 +/– 50.1 3.2E-04 0.97
2xRheobase: 2nd inst. freq., Hz 36.4 +/– 12.2 53.7 +/– 37.2 4.3E-02 0.63 101.3 +/– 50.7 37.2 +/– 11.6 3.8E-04 0.91
2xRheobase: adaptation index 54.1 +/– 11.2 80.0 +/– 10.4 1.2E-12 0.95 91.0 +/– 1.1 75.6 +/– 11.2 8.4E-03 1.00
2xRheobase: adaptation tau, ms 20.9 +/– 14.2 6.9 +/– 5.0 2.3E-05 0.86 4.6 +/– 1.7 8.6 +/– 7.1 0.23
IFavg fit: saturation freq, Hz 59.0 +/– 20.0 78.8 +/– 37.6 4.6E-02 0.70
IFavg fit: 1/slope 175.5 +/– 92.5 348.2 +/– 295.5 0.05
IFavg fit: rheobase, pA 196.3 +/– 76.2 162.6 +/– 71.9 4.6E-02 0.64
IFinst fit: saturation freq, Hz 758.1 +/– 967.6 306.5 +/– 201.6 1.4E-02 0.63
IFinst fit: 1/slope 1817.0 +/– 2341.1 332.3 +/– 643.0 5.8E-04 0.77
IFinst fit: rheobase, pA 215.3 +/– 133.2 172.9 +/– 82.0 0.26
IFinst fit slope/IFavg fit slope 10.78 +/– 8.50 1.27 +/– 1.83 2.9E-07 0.95 0.05 +/– 0.05 1.44 +/– 1.72 3.5E-04 1.00
A comparison of physiological properties of CT and CC neurons (left) and CC1 and CC2 neurons (right). P values of t-tests and ROC areas for each differing parameter (P < 0.05) are listed. Parameters differing significantly after the Bonferroni correction (P < 0.0031) for are indicated in bold. Number of neurons are in parentheses. RMP, resting membrane potential; AHP, after hyperpolarization.

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 Layer 6a barrel cortex pyramidal corticothalamic neuron with large terminal arbors fast AHP amplitude (mV) -13.7 ± 3.4 (34) 13.7 (mV) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex layer 6a corticocortical pyramidal neuron with infragranular arborization axons fast AHP amplitude (mV) -9.4 ± 4.2 (38) 9.4 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Layer 6a barrel cortex pyramidal corticothalamic neuron with large terminal arbors slow AHP amplitude (mV) -17.1 ± 2.9 (34) 17.1 (mV) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex layer 6a corticocortical pyramidal neuron with infragranular arborization axons slow AHP amplitude (mV) -15.5 ± 4.5 (38) 15.5 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Layer 6a barrel cortex pyramidal corticothalamic neuron with large terminal arbors resting membrane potential (mV) -70.2 ± 3.6 (34) -70.2 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Layer 6a barrel cortex pyramidal corticothalamic neuron with large terminal arbors maximum firing rate (Hz) 39.0 ± 14.8 (34) 39.0 (Hz) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex layer 6a corticocortical pyramidal neuron with infragranular arborization axons resting membrane potential (mV) -70.5 ± 4.5 (38) -70.5 (mV) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex layer 6a corticocortical pyramidal neuron with infragranular arborization axons maximum firing rate (Hz) 48.9 ± 12.8 (38) 48.9 (Hz) Data Table
Neocortex pyramidal cell layer 5-6 Layer 6a barrel cortex pyramidal corticothalamic neuron with large terminal arbors adaptation percent (first/last ISI) 54.1 ± 11.2 (34) 54.1 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex layer 6a corticocortical pyramidal neuron with infragranular arborization axons adaptation percent (first/last ISI) 80.0 ± 10.4 (38) 80.0 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Layer 6a barrel cortex pyramidal corticothalamic neuron with large terminal arbors input resistance (MΩ) 146.2 ± 47.0 (34) 146.2 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex layer 6a corticocortical pyramidal neuron with infragranular arborization axons input resistance (MΩ) 152.1 ± 56.2 (38) 152.1 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Layer 6a barrel cortex pyramidal corticothalamic neuron with large terminal arbors membrane time constant (ms) 12.0 ± 2.7 (34) 12.0 (ms) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex layer 6a corticocortical pyramidal neuron with infragranular arborization axons membrane time constant (ms) 16.5 ± 4.0 (38) 16.5 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Layer 6a barrel cortex pyramidal corticothalamic neuron with large terminal arbors rheobase (pA) 195.6 ± 79.8 (34) 195.6 (pA) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex layer 6a corticocortical pyramidal neuron with infragranular arborization axons rheobase (pA) 133.4 ± 56.5 (38) 133.4 (pA) Data Table
Neocortex pyramidal cell layer 5-6 Layer 6a barrel cortex pyramidal corticothalamic neuron with large terminal arbors spike amplitude from resting (mV) 101.7 ± 6.7 (34) 101.7 (mV) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex layer 6a corticocortical pyramidal neuron with infragranular arborization axons spike amplitude from resting (mV) 102.0 ± 8.8 (38) 102.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Layer 6a barrel cortex pyramidal corticothalamic neuron with large terminal arbors first spike latency (ms) 67.9 ± 22.1 (34) 67.9 (ms) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex layer 6a corticocortical pyramidal neuron with infragranular arborization axons first spike latency (ms) 137.1 ± 50.6 (38) 137.1 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Layer 6a barrel cortex pyramidal corticothalamic neuron with large terminal arbors spike half-width (ms) 0.77 ± 0.12 (34) 0.77 (ms) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex layer 6a corticocortical pyramidal neuron with infragranular arborization axons spike half-width (ms) 1.02 ± 0.16 (38) 1.02 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Layer 6a barrel cortex pyramidal corticothalamic neuron with large terminal arbors spike max rise slope (mV/ms) 99.3 ± 18.5 (34) 99.3 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex layer 6a corticocortical pyramidal neuron with infragranular arborization axons spike max rise slope (mV/ms) 105.1 ± 22.6 (38) 105.1 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 Layer 6a barrel cortex pyramidal corticothalamic neuron with large terminal arbors spike max decay slope (mV/ms) -79.1 ± 13.8 (34) 79.1 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex layer 6a corticocortical pyramidal neuron with infragranular arborization axons spike max decay slope (mV/ms) -50.7 ± 13.2 (38) 50.7 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 Layer 6a barrel cortex pyramidal corticothalamic neuron with large terminal arbors spike threshold (mV) -30.4 ± 5.0 (34) -30.4 (mV) Data Table
Neocortex pyramidal cell layer 5-6 barrel cortex layer 6a corticocortical pyramidal neuron with infragranular arborization axons spike threshold (mV) -32.2 ± 4.7 (38) -32.2 (mV) Data Table