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Article: Inter- and intralaminar subcircuits of excitatory and inhibitory neurons in layer 6a of the rat barrel cortex.

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Kumar P; Ohana O
J. Neurophysiol., 2008



TABLE 3.Physiological parameters of L6iL6 and L6iL4 interneurons
Physiological Parameters L6iL6 (9) L6iL4 (9) P Value ROC Area L6i (32) L6e (72) P Value ROC Area
RMP, mV –68.5 +/– 4.5 –67.9 +/– 7.0 0.86 –68.5 +/– 4.6 –70.4 +/– 4.1 4.3E-02 0.61
Input resistance, MΩ 97.7 +/– 43.5 132.6 +/– 37.3 0.12 128.2 +/– 48.8 149.3 +/– 51.8 0.12
Membrane tau, ms 7.2 +/– 1.9 10.7 +/– 3.9 0.06 9.6 +/– 3.5 14.4 +/– 4.1 1.2E-07 0.83
Rheobase, pA 310.0 +/– 122.1 146.2 +/– 75.4 7.3E-03 0.89 205.2 +/– 124.7 162.8 +/– 74.8 0.15
AP1 amplitude, mV 74.1 +/– 5.5 82.6 +/– 6.8 2.0E-02 0.88 80.9 +/– 9.3 101.8 +/– 7.8 1.1E-20 0.96
AP1 latency, ms 17.3 +/– 7.8 76.6 +/– 44.9 4.4E-03 0.96 73.1 +/– 77.5 104.4 +/– 52.6 1.5E-05 0.72
AP1 half-width, ms 0.37 +/– 0.06 0.63 +/– 0.07 6.2E-06 1.00 0.54 +/– 0.16 0.90 +/– 0.19 5.3E-15 0.93
AP1 rise slope, mV/ms 67.4 +/– 18.9 78.3 +/– 13.5 0.22 76.9 +/– 21.9 102.4 +/– 20.8 1.9E-07 0.81
AP1 fall slope, mV/ms –117.8 +/– 24.8 –79.9 +/– 17.2 4.1E-03 0.93 –94.5 +/– 27.2 –64.1 +/– 19.6 4.9E-09 0.82
AP1 threshold-absolute, mV –35.3 +/– 6.2 –37.6 +/– 6.2 0.49 –36.4 +/– 5.5 –31.3 +/– 4.9 1.1E-05 0.76
AP1 threshold-relative, mV 31.0 +/– 3.4 30.5 +/– 4.1 0.80 32.0 +/– 4.9 39.1 +/– 4.5 1.3E-10 0.87
AP1 fAHP amplitude, mV –22.5 +/– 4.9 –17.2 +/– 4.8 0.06 –19.7 +/– 4.3 –11.4 +/– 4.4 2.6E-14 0.91
AP1 sAHP amplitude, mV –16.3 +/– 3.9
AP1 fAHP latency, ms 1.76 +/– 0.38 3.21 +/– 1.02 3.6E-03 0.96 3.0 +/– 2.0 6.8 +/– 5.0 2.2E-07 0.82
AP1 sAHP latency, ms 41.9 +/– 30.4
Max avg frequency, Hz 220.7 +/– 37.2 129.1 +/– 56.6 3.0E-03 0.96 146.7 +/– 76.6 44.4 +/– 14.5 2.6E-11 0.88
Max 1st inst. frequency, Hz 258.3 +/– 37.7 184.0 +/– 61.3 1.6E-02 0.84 221.8 +/– 65.4 187.0 +/– 71.1 1.1E-02 0.65
Max 2nd inst. frequency, Hz 249.8 +/– 39.1 175.0 +/– 55.4 1.3E-02 0.89 205.4 +/– 61.0 99.9 +/– 54.9 6.2E-10 0.88
2xRheobase: avg. freq., Hz 165.0 +/– 49.9 63.8 +/– 32.5 7.3E-04 0.96 86.2 +/– 71.1 26.5 +/– 6.4 4.1E-08 0.74
2xRheobase: 1st inst. freq., Hz 200.8 +/– 47.6 88.3 +/– 22.6 1.1E-04 1.00 127.9 +/– 65.1 106.3 +/– 67.1 3.8E-02 0.62
2xRheobase: 2nd inst. freq., Hz 191.0 +/– 52.7 83.0 +/– 30.2 5.1E-04 0.96 116.1 +/– 66.5 46.3 +/– 30.2 8.0E-10 0.87
2xRheobase: adaptation index 24.6 +/– 14.1 29.1 +/– 23.9 0.67 33.2 +/– 23.5 68.8 +/– 16.7 4.2E-12 0.88
2xRheobase: adaptation tau, ms 276.8 +/– 354.4 73.6 +/– 52.5 0.16 153.1 +/– 257.3 12.9 +/– 12.1 7.8E-08 0.90
IFavg fit: saturation freq, Hz 616.2 +/– 755.1 457.8 +/– 425.7 0.69 477.0 +/– 608.7 70.7 +/– 32.9 5.6E-12 0.97
IFavg fit: 1/slope 985.2 +/– 1764.9 1002.6 +/– 1132.7 0.81 960.5 +/– 1589.6 277.2 +/– 248.1 2.7E-02 0.65
IFavg fit: rheobase, pA 327.8 +/– 148.6 181.3 +/– 50.8 1.3E-02 0.89 241.8 +/– 133.6 176.4 +/– 74.9 5.0E-02 0.65
IFinst fit: saturation freq, Hz 397.0 +/– 132.7 812.3 +/– 980.2 0.29 508.6 +/– 535.1 476.9 +/– 644.9 5.9E-04 0.64
IFinst fit: 1/slope 301.3 +/– 222.6 1703.3 +/– 2401.8 0.06 813.1 +/– 1370.0 892.5 +/– 1668.8 0.06
IFinst fit: rheobase, pA 333.8 +/– 138.7 163.7 +/– 45.2 2.7E-04 1.00 219.0 +/– 126.5 188.9 +/– 105.1 0.11
IFinst fit slope/IFavg fit slope 1.15 +/– 0.81 1.49 +/– 0.85 0.44 1.35 +/– 0.97 4.38 +/– 6.72 1.4E-02 0.55
A comparison of physiological properties of L6iL6 and L6iL4 neurons (left) and of all excitatory and inhibitory L6 neurons (right). P values of t-tests and ROC areas for each differing parameter (P < 0.05) are listed. Parameters differing significantly after the Bonferroni correction (P < 0.0031) are indicated in bold.

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex interneuron deep barrel cortex layer 6a GABAergic inhibitory interneuron fast AHP amplitude (mV) -19.7 ± 4.3 (32) 19.7 (mV) Data Table
Neocortex interneuron deep barrel cortex layer 6a GABAergic inhibitory interneuron maximum firing rate (Hz) 146.7 ± 76.6 (32) 146.7 (Hz) Data Table
Neocortex interneuron deep barrel cortex layer 6a GABAergic inhibitory interneuron resting membrane potential (mV) -68.5 ± 4.6 (32) -68.5 (mV) Data Table
Neocortex interneuron deep barrel cortex layer 6a GABAergic inhibitory interneuron input resistance (MΩ) 128.2 ± 48.8 (32) 128.2 (MΩ) Data Table
Neocortex interneuron deep barrel cortex layer 6a GABAergic inhibitory interneuron membrane time constant (ms) 9.6 ± 3.5 (32) 9.6 (ms) Data Table
Neocortex interneuron deep barrel cortex layer 6a GABAergic inhibitory interneuron rheobase (pA) 205.2 ± 124.7 (32) 205.2 (pA) Data Table
Neocortex interneuron deep barrel cortex layer 6a GABAergic inhibitory interneuron spike amplitude (mV) 80.9 ± 9.3 (32) 80.9 (mV) Data Table
Neocortex interneuron deep barrel cortex layer 6a GABAergic inhibitory interneuron first spike latency (ms) 73.1 ± 77.5 (32) 73.1 (ms) Data Table
Neocortex interneuron deep barrel cortex layer 6a GABAergic inhibitory interneuron spike half-width (ms) 0.54 ± 0.16 (32) 0.54 (ms) Data Table
Neocortex interneuron deep barrel cortex layer 6a GABAergic inhibitory interneuron spike max rise slope (mV/ms) 76.9 ± 21.9 (32) 76.9 (mV/ms) Data Table
Neocortex interneuron deep barrel cortex layer 6a GABAergic inhibitory interneuron spike max decay slope (mV/ms) -94.5 ± 27.2 (32) 94.5 (mV/ms) Data Table
Neocortex interneuron deep barrel cortex layer 6a GABAergic inhibitory interneuron spike threshold (mV) -36.4 ± 5.5 (32) -36.4 (mV) Data Table