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Article: Age-related enhancement of the slow outward calcium-activated potassium current in hippocampal CA1 pyramidal neurons in vitro.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Power JM; Wu WW; Sametsky E; Oh MM; Disterhoft JF J. Neurosci., 2002
Table 3.
Effect of nimodipine on young and aging neurons
| AHP tail measures | Young | Aging | pvalues | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Mean | SEM | n | Mean | SEM | n | T | F | U | |
| sI AHP–aCSF | |||||||||
| Peak amplitude (pA) | 214.8 | 21.0 | 30 | 353.6 | 27.5 | 35 | 0.0002 | 0.0567 | 0.0005 |
| Latency to peak amplitude (msec) | 403.4 | 33.4 | 30 | 445.8 | 33.9 | 35 | 0.3796 | ||
| 200 msec amplitude (pA) | 189.5 | 23.6 | 30 | 317.3 | 43.2 | 35 | 0.0008 | 0.0704 | |
| 1 sec amplitude (pA) | 143.2 | 15.8 | 30 | 262.4 | 23.5 | 35 | 0.0096 | 0.0002 | |
| 2 sec amplitude (pA) | 74.0 | 11.1 | 30 | 128.5 | 18.1 | 35 | 0.0021 | 0.0095 | |
| Area (pC) | 253.7 | 36.9 | 30 | 646.8 | 67.4 | 35 | 0.0012 | 0.0005 | |
| With nimodipine | |||||||||
| Peak amplitude (pA) | 164.5 | 22.9 | 25 | 266.0 | 26.7 | 31 | 0.007 | 0.1859 | |
| Latency to peak amplitude (msec) | 475.8 | 37.1 | 25 | 460.9 | 38.8 | 31 | 0.785 | ||
| 200 msec amplitude (pA) | 127.6 | 24.0 | 25 | 226.4 | 26.3 | 31 | 0.009 | 0.3072 | |
| 1 sec amplitude (pA) | 117.3 | 17.7 | 25 | 190.0 | 21.5 | 31 | 0.014 | 0.1231 | |
| 2 sec amplitude (pA) | 59.4 | 9.4 | 25 | 107.8 | 15.5 | 31 | 0.0027 | 0.040 | |
| Area (pC) | 286.5 | 46.0 | 25 | 465.9 | 57.4 | 31 | 0.022 | 0.0953 | |
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Age-related changes in theI AHP–sI AHP were replicated and reported in this table. The mean, SEM, and number of neurons recorded (n) are given for young and aging neurons. Statistical analyses were performed using unpaired t test (T), F test (F), and Mann-Whitney U test (U) as appropriate. Significant p values are highlighted in bold.
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
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