Article: Elevated postsynaptic [Ca2+]i and L-type calcium channel activity in aged hippocampal neurons: relationship to impaired synaptic plasticity.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Thibault O; Hadley R; Landfield PW J. Neurosci., 2001
Young-adult (n = 15) | Aged (n = 16) | |
---|---|---|
Input resistance (MΩ) | 58.9 ± 3.7 | 61.9 ± 3.3 |
Resting membrane potential (mV) | −58.7 ± 1.1 | −58.8 ± 1.3 |
Action potential threshold (μA) | 151 ± 15 | 181 ± 15 |
Action potential amplitude (mV) | 83.8 ± 1.3 | 81.9 ± 2.3 |
Action potential width at base (msec) | 2.3 ± 0.2 | 2.4 ± 0.1 |
Action potentials during 20 sec train (n) | 134.6 ± 8.4 | 126.9 ± 8.1 |
Action potentials during FFearly (n) | 14 ± 0 | 14 ± 0 |
Action potentials during FFlate(n) | 11.2 ± 1.3 | 10.2 ± 1.3 |
Interval, slicing to imaging (hr) | 3.85 ± 0.4 | 4.3 ± 0.3 |
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All values are mean ± SEM. No significant age-dependent differences were detected. Threshold was the synaptic stimulation electrode current necessary to trigger a Na+ action potential. Action potential amplitude was measured from the peak of the EPSP. Action potential number values (n) were obtained during the 7 Hz suprathreshold train of synaptic activation.