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Article: Elevated postsynaptic [Ca2+]i and L-type calcium channel activity in aged hippocampal neurons: relationship to impaired synaptic plasticity.

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Thibault O; Hadley R; Landfield PW
J. Neurosci., 2001


Table 2.

Neuronal parameters in patched-clamped control and Bay K8644-treated CA1 neurons

DMSO (n = 9) Bay K8644
AHP amplitude at 750 msec (mV) −1.9  ± 0.4 −3.6  ± 0.5* (n = 15)
Input resistance (MΩ) 105.8  ± 14.9 91.5  ± 10.4 (n = 15)
Stimulation threshold (μA) 207  ± 35.3 212  ± 75.1 (n = 15)
Subthreshold 7 Hz stimulation
 FFearly (%) 91.9  ± 23.1 98.3  ± 14.4
 FFlate (%) 66.8  ± 21.0 55.3  ± 14.5
 FFearly, membrane potential (mV) −70.9  ± 0.2 −71.1  ± 0.1 (n = 8)
 FFlate, membrane potential (mV) −70.6  ± 0.3 −68.7  ± 0.5 (n = 8)
Suprathreshold 7 Hz stimulation
 FFearly, membrane potential (mV) −71.1  ± 0.5 −69.7  ± 0.4 (n = 9)
 FFlate, membrane potential (mV) −67.3  ± 0.7 −61.7  ± 0.92-160 (n = 9)
Suprathreshold 7 Hz stimulation + current injection
 FFearly, membrane potential (mV) N/A −71.6  ± 0.8 (n = 6)
 FFlate, membrane potential (mV) N/A −71.1  ± 0.3 (n = 6)

  • All values are mean ± SEM.

  • ↵* p < 0.05;

  • ↵F2-160 p < 0.001 for DMSO versus Bay K8644 effect. Values for FF or membrane potential are 2 sec averages obtained during the first 2 sec and last 2 sec periods of a 20 sec train of 7 Hz of synaptic activation. N/A, Not applicable.


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