Comparison of the mean EPSC amplitude and mean spike threshold parameters measured from dynamic clamp experiments.
Cell type
N cells
N events
EPSC amplitude [nA]
Spike threshold [mV]
I Cont
8
26
0.296±0.011 [0.17 : 0.38]
-33.7±0.5 [-39.2 : -28.4]
I EtOH
9
26
0.352±0.016 [0.20 : 0.49]
-35.8±0.6 [-42.2 : -31.2]
II Cont
5
24
0.223±0.007 [0.15 : 0.27]
-35.7±0.4 [-41.2 : -33.4]
II EtOH
9
24
0.256±0.014 [0.11 : 0.36]
-35.2±0.4 [-40.0 : -31.8]
III Cont
9
27
0.373±0.019 [0.17 : 0.59]
-30.3±0.5 [-35.2 : -25.2]
III EtOH
13
27
0.503±0.025 [0.25 : 0.75]
-31.5±0.7 [-41.8 : -24.9]
For each cell type and treatment group the number of cells and number of spike events are shown. In average, each cell produced 20 spikes per stimulus sweep, but the number of possible event locations was higher. Mean EPSC amplitudes are consistently higher for the neurons from the alcohol dependent group (indicated by bold-italic numbers). No significant change is observed in the mean spike threshold. Values are expressed as means ± S.E.M. (unpaired t-test, p<0.05).
