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Article: Cortical slow oscillatory activity is reflected in the membrane potential and spike trains of striatal neurons in rats with chronic nigrostriatal lesions.

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Tseng KY; Kasanetz F; Kargieman L; Riquelme LA; Murer MG
J. Neurosci., 2001


Table 1.

Electrophysiological properties of intracellularly recorded striatal neurons in control and 6-hydroxydopamine-lesioned rats

Control 6-OHDA
Number of silent neurons 131-a    4  
Number of neurons firing spontaneously 14    27  
Action potential amplitude (mV)1-b 50.3  ± 1.8 50.9  ± 0.9
Action potential duration (msec)1-c 0.85  ± 0.03 0.81  ± 0.03
Threshold (spontaneous firing) (mV)1-d −54.8  ± 1.0 −54.5  ± 0.8
Input resistance (MΩ)1-e 53.0  ± 3.3 51.9  ± 4.7
Silent neurons
 Voltage in the down state (mV) −87.4  ± 3.5 −87.4  ± 4.3
 Voltage in the up state (mV) −77.5  ± 3.8 −76.8  ± 4.7
Spontaneously active neurons
 Voltage in the down state (mV) −82.4  ± 3.1 −73.3  ± 1.81-f
 Voltage in the up state (mV) −69.7  ± 2.1 −63.1  ± 1.31-g
Duration of the recordings (minutes, mean ± SEM, and range)1-h 49  ± 8 (11–179) 51  ± 9 (11–208)

  • Data are mean ± SEM. Spike measures were taken from spontaneously active neurons.

  • ↵F1-a p = 0.004 Fisher exact probability test.

  • ↵F1-b Measured from threshold.

  • ↵F1-c Measured at half maximal amplitude.

  • ↵F1-d Defined as the membrane potential at which the rate of voltage change exceeded 4 V/sec (Wickens and Wilson, 1998).

  • ↵F1-e Measured by applying depolarizing current pulses during the down state.

  • ↵F1-f p = 0.012, two-tailed Student's t test.

  • ↵F1-g p = 0.046, two-tailed Student's t test.

  • ↵F1-h Includes the time spent in the application of Neurobiotin.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other Neostriatum neuron spike half-width (msec) 0.85 ± 0.03 (14) 0.85 (ms) Data Table
Other Neostriatum neuron spike threshold -54.8 ± 1.0 (14) -54.8 (mV) Data Table
Other Neostriatum neuron input resistance (MΩ) 53.0 ± 3.3 (14) 53.0 (MΩ) Data Table
Other Neostriatum neuron spike amplitude (mV) 50.3 ± 1.8 (14) 50.3 (mV) Data Table