Article: Free Fatty Acid Effects on the Atrial Myocardium: Membrane Ionic Currents Are Remodeled by the Disruption of T-Tubular Architecture.
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O'Connell RP; Musa H; Gomez MS; Avula UM; Herron TJ; Kalifa J; Anumonwo JM
PLoS ONE, 2015
10.1371/journal.pone.0133052.t001
Electrophysiological properties of atrial myocytes incubated in palmitic (PA), stearic (SA), oleic (OA) acids and vehicle control (CTL).
|
RMP (mV) |
AP Amplitude (mV) |
AP Overshoot (mV) |
dv/dtmax (mV/msec) |
Cell Cap (pF) |
CTL n = 9; N = 3 |
-78.7 ± 0.90 |
106.5 ± 3.63 |
28.0 ± 3.44 |
227.9 ± 12.6 |
59.2 ± 2.94 |
PA n = 12; N = 3 |
-79.5 ± 0.81 |
118.8 ± 4.20 |
36.3 ± 3.26 |
231.8 ± 19.4 |
63.7 ± 5.15 |
CTL n = 22; N = 5 |
-79.2 ± 0.6 |
126.6 ± 2.52 |
34.0 ± 2.04 |
223.9 ± 13.1 |
63.1 ± 3.08 |
SA n = 24; N = 5 |
-80.3 ± 0.7 |
119.0 ± 2.92 |
34.3 ± 2.54 |
210.0 ± 13.8 |
53.8 ± 2.55* |
CTL n = 6; N = 2 |
-77.8 ± 0.74 |
119.0 ± 2.68 |
37.3 ± 1.92 |
192.5 ± 18.3 |
71.1 ± 5.98 |
OA n = 5; N = 2CTL n = 6; N = 2 |
-79.5 ± 1.21-77.8 ± 0.74 |
123.2 ± 4.02119.0 ± 2.68 |
38.0 ± 2.9237.3 ± 1.92 |
199.7 ± 12.0192.5 ± 18.3 |
64.9 ± 2.7971.1 ± 5.98 |
OA n = 5; N = 2 |
-79.5 ± 1.21 |
123.2 ± 4.02 |
38.0 ± 2.92 |
199.7 ± 12.0 |
64.9 ± 2.79 |
Acquisition of Resting Membrane Potential (RMP), Action Potential (AP) Amplitude, Action Potential Overshoot, dv/dtmax, and Cell Capacitance by patch clamp is presented with animal matched controls (CTL). (*p<0.05).
Inferred neuron-electrophysiology data values