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Article: Extracellular calcium modulates persistent sodium current-dependent burst-firing in hippocampal pyramidal neurons.

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Su H; Alroy G; Kirson ED; Yaari Y
J. Neurosci., 2001


Table 1.

Effects of low [Ca2+]o on intrinsic membrane properties of CA1 PCs

2 Ca2+ 0 Ca2+
Resting V M, mV −64.3  ± 3.8 −64.6  ± 3.8
R N, MΩ 28.4  ± 9.1 30.2  ± 6.7
τm, msec 13.7  ± 5.2 14.6  ± 5.5
Spike threshold, mV −52.3  ± 3.8 −52.5  ± 4.0
Spike amplitude, mV 87.0  ± 5.9 87.5  ± 6.6
Fast AHP, mV −56.0  ± 4.8 −50.1  ± 5.0*
ADP, mV · msec 171.7  ± 46.3 261.5  ± 117.1*

  • Recordings from each PC (n = 40) were made first in standard saline (2 Ca2+) and then after ∼30 min of perfusion with nominally Ca2+-free saline (0 Ca2+). All entries are expressed as mean ±sd. Resting V M andR N are resting membrane potential and input resistance, respectively. τm is the passive time constant of the membrane measured at resting V M. Fast AHP is the membrane potential reached at the end of fast spike repolarization. ADP is the slow depolarizing potential that follows the fast AHP (see Materials and Methods).

  • ↵* Significantly different (p < 0.05) from control.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 pyramidal cell spike threshold (mV) -52.3 ± 3.8 (40) -52.3 (mV) Data Table
Hippocampus CA1 pyramidal cell spike amplitude from resting (mV) 87.0 ± 5.9 (40) 87.0 (mV) Data Table
Hippocampus CA1 pyramidal cell fast AHP voltage (mV) -56.0 ± 4.8 (40) -56.0 (mV) Data Table
Hippocampus CA1 pyramidal cell resting membrane potential (mV) -64.3 ± 3.8 (40) -64.3 (mV) Data Table
Hippocampus CA1 pyramidal cell input resistance (MΩ) 28.4 ± 9.1 (40) 28.4 (MΩ) Data Table
Hippocampus CA1 pyramidal cell membrane time constant (msec) 13.7 ± 5.2 (40) 13.7 (ms) Data Table