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Article: D(2)-like dopamine receptors differentially regulate unitary IPSCs depending on presynaptic GABAergic neuron subtypes in rat nucleus accumbens shell.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Kohnomi S; Koshikawa N; Kobayashi M
J. Neurophysiol., 2012


Table 1.

Intrinsic electrophysiological properties of MS and FS neurons

Medium Spiny Neuron n Fast-Spiking Neuron n
Vm, mV −82.8 ± 0.6 97 −81.7 ± 1.1 24
Input resistance, MΩ 258.5 ± 17.0 97 145.7 ± 19.6*** 24
Action potential
    Threshold, mV −48.0 ± 0.6 97 −48.4 ± 1.3 24
    Amplitude, mV 73.6 ± 1.3 97 62.6 ± 2.7*** 24
    Half-duration, ms 1.42 ± 0.02 97 0.70 ± 0.04*** 24
    AHP amplitude, mV 6.7 ± 0.5 97 18.1 ± 1.7*** 24
    Rheobase, pA 118.0 ± 6.1 83 185.2 ± 19.8** 21
Repetitive firing
    Maximal firing rate, Hz 32.4 ± 1.2 81 86.2 ± 6.2*** 21
    F–I slope, Hz/pA 0.46 ± 0.03 83 0.79 ± 0.10** 21

  • Values are means ± SE. MS, medium spiny; FS, fast spiking; Vm, resting membrane potential; AHP, afterhyperpolarization; F–I, frequency-current.

  • ↵** P < 0.01,

  • ↵*** P < 0.001, Student's t-test.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Nucleus accumbens medium spiny neuron Nucleus accumbens medium spiny neuron projecting to adjacent medium spiny neurons spike threshold (mV) -48.0 ± 0.6 (97) -48.0 (mV) Data Table
Nucleus accumbens shell neuron Nucleus Accumbens fast-spiking parvalbumin-expressing GABAergic neuron projecting to medium spiny neurons. spike threshold (mV) -48.4 ± 1.3 (24) -48.4 (mV) Data Table
Nucleus accumbens medium spiny neuron Nucleus accumbens medium spiny neuron projecting to adjacent medium spiny neurons resting membrane potential (mV) -82.8 ± 0.6 (97) -82.8 (mV) Data Table
Nucleus accumbens medium spiny neuron Nucleus accumbens medium spiny neuron projecting to adjacent medium spiny neurons spike amplitude (mV) 73.6 ± 1.3 (97) 73.6 (mV) Data Table
Nucleus accumbens shell neuron Nucleus Accumbens fast-spiking parvalbumin-expressing GABAergic neuron projecting to medium spiny neurons. spike amplitude (mV) 62.6 ± 2.7 (24) 62.6 (mV) Data Table
Nucleus accumbens medium spiny neuron Nucleus accumbens medium spiny neuron projecting to adjacent medium spiny neurons spike half-width (ms) 1.42 ± 0.02 (97) 1.42 (ms) Data Table
Nucleus accumbens shell neuron Nucleus Accumbens fast-spiking parvalbumin-expressing GABAergic neuron projecting to medium spiny neurons. spike half-width (ms) 0.7 ± 0.04 (24) 0.7 (ms) Data Table
Nucleus accumbens medium spiny neuron Nucleus accumbens medium spiny neuron projecting to adjacent medium spiny neurons AHP amplitude (mV) 6.7 ± 0.5 (97) 6.7 (mV) Data Table
Nucleus accumbens shell neuron Nucleus Accumbens fast-spiking parvalbumin-expressing GABAergic neuron projecting to medium spiny neurons. AHP amplitude (mV) 18.1 ± 1.7 (24) 18.1 (mV) Data Table
Nucleus accumbens medium spiny neuron Nucleus accumbens medium spiny neuron projecting to adjacent medium spiny neurons rheobase (pA) 118.0 ± 6.1 (97) 118.0 (pA) Data Table
Nucleus accumbens shell neuron Nucleus Accumbens fast-spiking parvalbumin-expressing GABAergic neuron projecting to medium spiny neurons. rheobase (pA) 185.2 ± 19.8 (24) 185.2 (pA) Data Table
Nucleus accumbens shell neuron Nucleus Accumbens fast-spiking parvalbumin-expressing GABAergic neuron projecting to medium spiny neurons. resting membrane potential (mV) -81.7 ± 1.1 (24) -81.7 (mV) Data Table
Nucleus accumbens medium spiny neuron Nucleus accumbens medium spiny neuron projecting to adjacent medium spiny neurons maximum firing rate (Hz) 32.4 ± 1.2 (97) 32.4 (Hz) Data Table
Nucleus accumbens shell neuron Nucleus Accumbens fast-spiking parvalbumin-expressing GABAergic neuron projecting to medium spiny neurons. maximum firing rate (Hz) 86.2 ± 6.2 (24) 86.2 (Hz) Data Table
Nucleus accumbens medium spiny neuron Nucleus accumbens medium spiny neuron projecting to adjacent medium spiny neurons FI slope (Hz/pA) 0.46 ± 0.03 (97) 460.0 (Hz/nA) Data Table
Nucleus accumbens shell neuron Nucleus Accumbens fast-spiking parvalbumin-expressing GABAergic neuron projecting to medium spiny neurons. FI slope (Hz/pA) 0.79 ± 0.1 (24) 790.0 (Hz/nA) Data Table
Nucleus accumbens medium spiny neuron Nucleus accumbens medium spiny neuron projecting to adjacent medium spiny neurons input resistance (MΩ) 258.5 ± 17.0 (97) 258.5 (MΩ) Data Table
Nucleus accumbens shell neuron Nucleus Accumbens fast-spiking parvalbumin-expressing GABAergic neuron projecting to medium spiny neurons. input resistance (MΩ) 145.7 ± 19.6 (24) 145.7 (MΩ) Data Table