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Article: Excitatory role of the hyperpolarization-activated inward current in phasic and tonic firing of rat supraoptic neurons.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Ghamari-Langroudi M; Bourque CW J. Neurosci., 2000
Table 1.
Effects of ZD 7288 on membrane potential and spike discharge
| n | Control | ZD 7288 | p value | |
|---|---|---|---|---|
| Silent cells | ||||
| V m in silent cells held >−65 mV (mV) | 6 | −61.7 ± 1.8 | −62.4 ± 1.6 | 0.320 |
| V m in silent cells held ≤−65 mV (mV) | 4 | −80.8 ± 10.3 | −85.0 ± 11.6 | 0.048 |
| Continuously active cells | ||||
| V m (mV) | 6 | −57.8 ± 1.1 | −59.9 ± 1.6 | 0.013 |
| Phasically active cells | ||||
| V mduring active phase (mV) | 5 | −57.5 ± 1.0 | −61.8 ± 1.9 | 0.031 |
| Minimum V mduring silent phase (mV) | 5 | −62.8 ± 1.3 | −63.0 ± 1.4 | 0.874 |
| Steady state frequency (Hz) | 5 | 8.6 ± 1.2 | 5.1 ± 0.48 | 0.016 |
| Burst length (sec) | 5 | 47.0 ± 8.8 | 10.8 ± 2.7 | 0.013 |
| Silent interval (sec) | 5 | 44.8 ± 12.7 | 53.4 ± 13.6 | 0.002 |
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The table reports the mean (±SEM) effects of ZD 7288 on membrane potential (V m), steady-state firing frequency, and phasic bursting parameters observed in a number (n) of MNCs. Group values were compared using a paired t test, and the p values are reported. Significant changes (p< 0.05) are noted by the bolded p values.
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
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