TABLE 1.Summary of the effects of different anesthetics on dendritic properties in vitro
|
|
|||
| Dendritic Properties | Urethane, 20 mM | Pentobarbital, 200 µM | Ketamine, 400 µM/Xylazine, 50 µM |
|
|
|||
| Somatic recordings | |||
| Critical frequency (CF) | +24.0 ± 2.9% (n = 16)* | +16.4 ± 3.2% (n = 12)* | –22.2 ± 3.2% (n = 14)* |
| ADP amplitude | –10.7 ± 5.7% (n = 16)* | –54.0 ± 7.5% (n = 12)* | +151.0 ± 19.3% (n = 14)* |
| Dendritic recordings | |||
| Ca2+ spike amplitude | –9.2 ± 5.5% (n = 4) | –12.8 ± 9.5% (n = 3) | +8.7 ± 6.5% (n = 4) |
| Ca2+ spike half-width | –0.8 ± 24.2% (n = 3) | –55.2 ± 21.8% (n = 2) | +71.1 ± 48.8% (n = 5) |
| Ca2+ spike integral | |||
| CF test | –38.5 ± 8.9% (n = 5)* | –52.4 ± 2.6% (n = 4)* | +80.5 ± 23.4% (n = 5)* |
| Dendritic current injection | –33.9 ± 8.6% (n = 5)* | –42.5 ± 10.4% (n = 3)* | +106.5 ± 53.4% (n = 4)* |
| Propagation properties | |||
| Back-AP half-width | –5.2 ± 3.4% (n = 5) | –8.0 ± 7.5% (n = 3) | +32.5 ± 16.5% (n = 3) |
| Back-AP amplitude | +1.5 ± 1.7% (n = 5) | +1.0 ± 3.2% (n = 3) | –12.1 = 7.9% (n = 3) |
Values are percentages ± SE (n values in parentheses) and represent the change compared with control values (no change would be 0%). Somatic recordings
were pooled from dual somatic/dendritic and single somatic recordings. Action potential (AP) statistics were calculated from
a single AP or the first AP in a train.
* P < 0.05 with one-tailed paired Student's t-test (SE).