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Article: Effect of common anesthetics on dendritic properties in layer 5 neocortical pyramidal neurons.

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Potez S; Larkum ME
J. Neurophysiol., 2008



TABLE 2.Summary of the effects of different anesthetics on firing properties in vitro


Firing Properties Control Urethane, 20 mM Pentobarbital, 200 µM Ketamine, 400 µM/Xylazine, 50 µM

Average sag amplitude, % 16.62 ± 1.09 (n = 43) 20.91 ± 1.48 (n = 16) 18.46 ± 1.51 (n = 12) 17.73 ± 2.19 (n = 14)
Rheobase, pA (current threshold) 353.37 ± 19.35 (n = 42) 403.13 ± 37.77 (n = 16) 658.33 ± 72.52 (n = 12)* 316.67 ± 34.98 (n = 14)
Burstiness, % 24.53 ± 4.67 (n = 43) 29.17 ± 6.72 (n = 16) 13.33 ± 7.00 (n = 12) 51.19 ± 7.51 (n = 14)*
Frequency adaptation, % 24.2 ± 5.6 (n = 27) 25.4 ± 12.5 (n = 11) 41.8 ± 11.4 (n = 9)* 86.5 ± 2.3 (n = 10)*
Rinput, MΩ 37.48 ± 2.39 (n = 42) 36.08 ± 4.12 (n = 16) 24.71 ± 1.67 (n = 12)* 38.49 ± 3.81 (n = 14)
Vm rest, mV –65.83 ± 0.446 (n = 42) –63.78 ± 1.56 (n = 16) –67.24 ± 0.884 (n = 12) –68.78 ± 1.04 (n = 14)*
AP half-width, ms 0.693 ± 0.0186 (n = 43) 0.675 ± 0.0194 (n = 16) 0.625 ± 0.0305 (n = 12) 0.836 ± 0.0476 (n = 14)*
AP peak amplitude, mV 90.52 ± 1.81 (n = 43) 88.65 ± 1.73 (n = 16) 87.62 ± 2.66 (n = 12) 65.31 ± 2.97 (n = 14)*
AP threshold, mV –44.56 ± 0.836 (n = 43) –41.32 ± 1.61 (n = 16)* –46.35 ± 1.75 (n = 12) –37.21 ± 1.52 (n = 14)*

Values are means ± SE (n values in parentheses) and correspond to parameters measured at the soma for long step (1 s) somatic current injections. Current pulses started at negative values and increased by steps of 100 pA after each sweep. Measurements relative to the AP were done for the first action potential of the sweep.

* P < 0.05 (SE).


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory barrel cortex pyramidal neurons sag ratio 16.62 ± 1.09 (43) 0.1662 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory barrel cortex pyramidal neurons rheobase 353.37 ± 19.35 (42) 353.37 (pA) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory barrel cortex pyramidal neurons other 24.53 ± 4.67 (43) 24.53 (None) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory barrel cortex pyramidal neurons adaptation percent (1 – first/last ISI) 24.2 ± 5.6 (27) 24.2 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory barrel cortex pyramidal neurons input resistance (MΩ) 37.48 ± 2.39 (42) 37.48 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory barrel cortex pyramidal neurons resting membrane potential (mV) -65.83 ± 0.446 (42) -65.83 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory barrel cortex pyramidal neurons spike half-width (ms) 0.693 ± 0.0186 (43) 0.693 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory barrel cortex pyramidal neurons spike amplitude (mV) 90.52 ± 1.81 (43) 90.52 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory barrel cortex pyramidal neurons spike threshold (mV) -44.56 ± 0.836 (43) -44.56 (mV) Data Table