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Article: Increased excitability of afferent neurons innervating rat urinary bladder after chronic bladder inflammation.

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Yoshimura N; de Groat WC
J. Neurosci., 1999


Table 1.

Membrane characteristics of bladder afferent neurons exhibiting TTX-resistant action potentials in control and CYP-treated rats

Control CYP-treated
No. of cells n = 30 n = 34
Diameter (μm) 23.6  ± 0.8 29.6  ± 1.0**
Input capacitance (pF) 28.2  ± 1.8 41.8  ± 3.1**
RMP (mV) −53.5  ± 2.0 −51.5  ± 1.7
Spike threshold (mV) −21.4  ± 0.9 −25.4  ± 0.5*
Spike duration (msec) 7.9  ± 0.5 6.6  ± 0.5
No. of action potentials (500 msec depolarization) 1.2  ± 0.2 12.3  ± 1.4**
No. of cells n  = 25 n  = 22
I A current density (pA/pF) (at 0 mV) 109.4  ± 9.4 42.9  ± 6.6**
Decay time constant (τ) of I A current (msec) 189.6  ± 8.8 201.2  ± 7.6
I KV current density (pA/pF) (at 0 mV) 52.8  ± 7.1 60.2  ± 6.1
  • Values are mean ± SEM. *p < 0.05 and **p < 0.01 indicate differences compared with control animals. RMP, Resting membrane potentials. Number of action potentials was obtained by injections of depolarizing current pulses (500 msec duration).


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Dorsal root ganglion cell resting membrane potential (mV) -53.5 ± 2.0 (30) -53.5 (mV) Data Table
Dorsal root ganglion cell spike threshold (mV) -21.4 ± 0.9 (30) -21.4 (mV) Data Table
Dorsal root ganglion cell spike width (msec) 7.9 ± 0.5 (30) 7.9 (ms) Data Table
Dorsal root ganglion cell cell diameter (μm) 23.6 ± 0.8 (30) 23.6 (um) Data Table
Dorsal root ganglion cell cell capacitance (pF) 28.2 ± 1.8 (30) 28.2 (pF) Data Table