AboutNeuron TypesElectrophysiology PropertiesArticlesFAQsData/APIGet Involved

Article: Ghrelin stimulation of growth hormone-releasing hormone neurons is direct in the arcuate nucleus.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Osterstock G; Escobar P; Mitutsova V; Gouty-Colomer LA; Fontanaud P; Molino F; Fehrentz JA; Carmignac D; Martinez J; Guerineau NC; Robinson IC; Mollard P; Méry PF
PLoS ONE, 2010


10.1371/journal.pone.0009159.t001 Effects of ghrelin on the properties of action potentials in GHRH neurons (n = 8).
Parameters Control Ghrelin 10 nM
Amplitude (mV) Threshold -45.7±3.4 -43.9±2.2
Peak 4.6±3.0 5.3±2.0
After hyperpolarisation -54.0±3.8 -51.6±3.1
Peak - threshold 49.8±3.5 49.7±2.9
AHP - threshold -7.7±1.1 -8.8±1.0
Duration (ms) Time-to-peak 5.92±0.46 6.17±0.34
Time-to-AHP 12.20±0.94 12.69±0.88
Half-width 1.60±0.13 1.63±0.19

Report miscurated data

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Paraventricular hypothalamic nucleus neurons arcuate hypothalamic nucleus growth hormone-releasing hormone neuron spike peak 4.6 ± 3.0 (8) 4.6 (mV) Data Table
Paraventricular hypothalamic nucleus neurons arcuate hypothalamic nucleus growth hormone-releasing hormone neuron AHP voltage -54.0 ± 3.8 (8) -54.0 (mV) Data Table
Paraventricular hypothalamic nucleus neurons arcuate hypothalamic nucleus growth hormone-releasing hormone neuron spike amplitude 49.8 ± 3.5 (8) 49.8 (mV) Data Table
Paraventricular hypothalamic nucleus neurons arcuate hypothalamic nucleus growth hormone-releasing hormone neuron AHP amplitude -7.7 ± 1.1 (8) 7.7 (mV) Data Table
Paraventricular hypothalamic nucleus neurons arcuate hypothalamic nucleus growth hormone-releasing hormone neuron spike rise time 5.92 ± 0.46 (8) 5.92 (ms) Data Table
Paraventricular hypothalamic nucleus neurons arcuate hypothalamic nucleus growth hormone-releasing hormone neuron spike decay time 12.2 ± 0.94 (8) -- Data Table
Paraventricular hypothalamic nucleus neurons arcuate hypothalamic nucleus growth hormone-releasing hormone neuron spike half-width 1.6 ± 0.13 (8) 1.6 (ms) Data Table
Paraventricular hypothalamic nucleus neurons arcuate hypothalamic nucleus growth hormone-releasing hormone neuron spike threshold -45.7 ± 3.4 (8) -45.7 (mV) Data Table