Article: Cyclophosphamide-induced bladder inflammation sensitizes and enhances P2X receptor function in rat bladder sensory neurons.

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Dang K; Lamb K; Cohen M; Bielefeldt K; Gebhart GF
J. Neurophysiol., 2008

TABLE 1.Passive and active electrical properties of LS and TL bladder neurons from CYP-treated and control rats



Property	Treatment	LS	TL

A. Current injection
RMP, mV	Control	–55.02 ± 2.1	–47.78 ± 1.0^*
	CYP	–55.34 ± 1.6	–49.61 ± 1.3
Spontaneous activity	Control	0/23 (0%)	0/23 (0%)
	CYP	11/31 (35%)^†	13/29 (45%)^†
Rheobase, pA	Control	146.1 ± 14.5	95.7 ± 7.5^*
	CYP	66.2 ± 6.2^†	50.6 ± 5.5^†
Rheobase, pA/pF	Control	5.67 ± 0.7	2.54 ± 0.2^*
	CYP	2.28 ± 0.3^†	1.14 ± 0.2^†
AP threshold, mV	Control	–24.5 ± 1.4	–23.3 ± 0.7
	CYP	–30.1 ± 0.8^†	–28.2 ± 1.0^†
AP amplitude, mV	Control	87.9 ± 4.1	87.4 ± 2.1
	CYP	93.4 ± 2.2	89.9 ± 3.0
AP duration, ms	Control	3.1 ± 0.2	3.2 ± 0.2
	CYP	4.2 ± 0.3^†	5.0 ± 0.6^†
Rheobase x 2 (APs)	Control	5.0 ± 0.9	6.3 ± 0.6
	CYP	10.7 ± 2.1^†	9.2 ± 0.7^†
B. ATP (100 µM)
Depolarization, mV	Control	24.5 ± 1.5	6.2 ± 1.2^*
	CYP	31.9 ± 1.5^†	14.1 ± 1.2^†
Number of APs	Control	8.9 ± 0.7	3.7 ± 1.4^*
	CYP	15.2 ± 2.1^†	13.5 ± 3.6^†
C. αβ-metATP (100 µM)
Depolarization, mV	Control	15.3 ± 1.4	5.4 ± 1.1^*
	CYP	25.6 ± 1.3^†	13.2 ± 1.2^†
Number of APs	Control	5.2 ± 0.7	2.4 ± 1.3^*
	CYP	12.9 ± 0.9^†	10.3 ± 1.4^†

Values are means ± SE, or percentages.

^* P < 0.05 versus LS counterparts;

^† P < 0.05 versus control (saline) treatment.

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Inferred neuron-electrophysiology data values

Neuron Type	Neuron Description	Ephys Prop	Extracted Value	Standardized Value	Content Source
Dorsal root ganglion cell	Lumbosacral dorsal root ganglion	resting membrane potential (mV)	-55.02 ± 2.1	-55.02 (mV)	Data Table
Dorsal root ganglion cell	thoracolumbar dorsal root ganglion	resting membrane potential (mV)	-47.78 ± 1.0	-47.78 (mV)	Data Table
Dorsal root ganglion cell	Lumbosacral dorsal root ganglion	rheobase (pA)	146.1 ± 14.5	146.1 (pA)	Data Table
Dorsal root ganglion cell	thoracolumbar dorsal root ganglion	rheobase (pA)	95.7 ± 7.5	95.7 (pA)	Data Table
Dorsal root ganglion cell	Lumbosacral dorsal root ganglion	spike threshold (mV)	-24.5 ± 1.4	-24.5 (mV)	Data Table
Dorsal root ganglion cell	thoracolumbar dorsal root ganglion	spike threshold (mV)	-23.3 ± 0.7	-23.3 (mV)	Data Table
Dorsal root ganglion cell	Lumbosacral dorsal root ganglion	spike amplitude (mV)	87.9 ± 4.1	87.9 (mV)	Data Table
Dorsal root ganglion cell	thoracolumbar dorsal root ganglion	spike amplitude (mV)	87.4 ± 2.1	87.4 (mV)	Data Table
Dorsal root ganglion cell	Lumbosacral dorsal root ganglion	spike width (ms)	3.1 ± 0.2	3.1 (ms)	Data Table
Dorsal root ganglion cell	thoracolumbar dorsal root ganglion	spike width (ms)	3.2 ± 0.2	3.2 (ms)	Data Table
Dorsal root ganglion cell	Lumbosacral dorsal root ganglion	other (mV)	24.5 ± 1.5	24.5 (None)	Data Table
Dorsal root ganglion cell	thoracolumbar dorsal root ganglion	other (mV)	6.2 ± 1.2	6.2 (None)	Data Table
Dorsal root ganglion cell	Lumbosacral dorsal root ganglion	other (mV)	15.3 ± 1.4	15.3 (None)	Data Table
Dorsal root ganglion cell	thoracolumbar dorsal root ganglion	other (mV)	5.4 ± 1.1	5.4 (None)	Data Table