Article: Membrane properties of striatal direct and indirect pathway neurons in mouse and rat slices and their modulation by dopamine.
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Planert H; Berger TK; Silberberg G
PLoS ONE, 2013
10.1371/journal.pone.0057054.t002
Membrane properties of mouse D1 and D2 MSNs.
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|
D1 MSNs (n = 32) |
D2 MSNs (n = 30) |
|
|
n |
mean |
SD |
n |
mean |
SD |
p-value |
| Rest potential when impaling cell (mV) |
24 |
-78.65 |
4.75 |
25 |
-78.91 |
3.93 |
0.834 |
| Baseline current (pA) |
30 |
-4.13 |
47.17 |
29 |
-6.25 |
73.16 |
0.895 |
| Baseline membrane potential for recordings (mV) |
32 |
-78.97 |
2.15 |
29 |
-79.70 |
2.97 |
0.266 |
| Amplitude of first AP (mV) |
29 |
78.50 |
7.73 |
29 |
78.77 |
9.42 |
0.907 |
| Duration of first AP (ms) |
29 |
1.83 |
0.42 |
29 |
1.75 |
0.49 |
0.523 |
| Width of first AP (ms) |
29 |
0.77 |
0.10 |
29 |
0.75 |
0.11 |
0.352 |
| Amplitude of second AP (mV) |
29 |
62.16 |
8.29 |
29 |
64.34 |
10.04 |
0.371 |
| Duration of second AP (ms) |
29 |
1.94 |
0.35 |
29 |
1.92 |
0.33 |
0.803 |
| Width of second AP (ms) |
29 |
1.00 |
0.18 |
29 |
0.97 |
0.15 |
0.472 |
| Amplitude change first to second AP (%) |
29 |
-20.75 |
7.90 |
29 |
-18.18 |
8.81 |
0.247 |
| AP duration change (%) |
29 |
7.34 |
11.70 |
29 |
12.40 |
14.55 |
0.150 |
| AP width change (%) |
29 |
29.42 |
13.55 |
29 |
30.28 |
9.80 |
0.782 |
| Input resistance at rest (MΩ) |
30 |
85.26 |
48.77 |
27 |
96.44 |
48.97 |
0.392 |
| Input resistance [depolarized] (MΩ ) |
31 |
131.70 |
57.79 |
28 |
151.37 |
71.51 |
0.248 |
| Input resistance [hyperpolarized] (MΩ ) |
31 |
50.67 |
29.46 |
28 |
59.90 |
28.87 |
0.230 |
| Membrane time constant at rest (ms) |
29 |
5.16 |
2.39 |
28 |
5.98 |
3.00 |
0.254 |
| Membrane time constant [depolarized] (ms) |
32 |
11.05 |
3.15 |
29 |
12.43 |
4.37 |
0.159 |
| Membrane time constant [hyperpolarized] (ms) |
31 |
1.84 |
1.08 |
29 |
2.54 |
2.11 |
0.114 |
| Membrane time constant for delta pulse (ms) |
30 |
4.84 |
2.43 |
29 |
5.87 |
3.38 |
0.186 |
| Threshold for APs (mV) |
32 |
-42.73 |
2.65 |
28 |
-44.29 |
4.44 |
0.112 |
| AP drop rate (%) |
30 |
-0.02 |
0.02 |
28 |
-0.02 |
0.02 |
0.668 |
|
Ramp current to first spike (pA)
|
31 |
332.93 |
127.30 |
29 |
257.53 |
87.11 |
0.010
|
|
Minimum step current for discharge (pA)
|
30 |
355.39 |
150.33 |
28 |
268.74 |
96.07 |
0.011
|
| Slope of current/frequency relationship (Hz/pA) |
30 |
0.12 |
0.08 |
27 |
0.15 |
0.09 |
0.174 |
Inferred neuron-electrophysiology data values
