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Article: Cyclophosphamide-induced bladder inflammation sensitizes and enhances P2X receptor function in rat bladder sensory neurons.

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Dang K; Lamb K; Cohen M; Bielefeldt K; Gebhart GF
J. Neurophysiol., 2008



TABLE 3.Current kinetics for LS and TL bladder sensory neurons from CYP-treated and control rats
Current Treatment ATP (30 µM)
 αβ-metATP (30 µM)
10–90% Rise Time, ms Tau 1, ms Tau 2, ms 10–90% Rise Time, ms Tau 1, ms Tau 1, ms
A. LS
Fast Control 22.9 ± 4 4,475 ± 402 n/a 630.8 ± 47 12,990 ± 2,011 n/a
CYP n/a n/a n/a n/a n/a n/a
Slow Control 226.7 ± 38 4,475 ± 402 n/a 630.8 ± 47 3,723 ± 535 n/a
CYP 125.2 ± 21* 6,820 ± 710* n/a 404.0 ± 37* 12,990 ± 2,011* n/a
Mixed Control 26.7 ± 3 194 ± 58 3,419 ± 827 28.3 ± 3 218 ± 40 n/a
CYP n/a n/a n/a n/a n/a n/a
B. TL
Fast Control 22.7 ± 2 217 ± 42 n/a 25.9 ± 3 215 ± 29 n/a
CYP 19.6 ± 3 196 ± 39 n/a 23.3 ± 2 223 ± 30 n/a
Slow Control 258.0 ± 48 3,933 ± 827 n/a 269.8 ± 34 4,179 ± 1,075 n/a
CYP 212.0 ± 19 2,953 ± 876 n/a 232.4 ± 18 3,287 ± 724 n/a
Mixed Control 27.6 ± 3 239 ± 33 2,931 ± 252 22.1 ± 4 247 ± 37 3,857 ± 856
CYP 24.3 ± 2 199 ± 21 3,473 ± 594 25.8 ± 3 212 ± 28 2,768 ± 594
Values are means ± SE.

* P < 0.05 versus the corresponding control group. n/a, not applicable.


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