TABLE 1.Intrinsic membrane and firing properties of identified cortical projection neurons
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CThal (1) | CTrig (2) | CStr (3) | Callosal (4) | |
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n | 18 | 19 | 28 | 16 |
Vm mV | –62.3 ± 0.4 | –63.6 ± 0.6 | –67.1 ± 0.6 | –67.1 ± 0.7 |
***3 | *3 | |||
***4 | ||||
Rin MOhm | 149.8 ± 5.2 | 143.3 ± 6.7 | 183.1 ± 13.3 | 157.9 ± 10.2 |
AP threshold, mV | –42.3 ± 0.5 *2 | –39.4 ± 0.6 | –35.5 ± 0.5 | –36.5 ± 0.7 |
***3 | ***3 | |||
***4 | *4 | |||
Half width, ms | 0.91 ± 0.03 | 1.02 ± 0.05 | 1.17 ± 0.02 | 1.11 ± 0.02 |
***3 | **3 | |||
***4 | ||||
Adaptation ratio | 0.96 ± 0.03 | 0.96 ± 0.05 | 0.33 ± 0.03 | 0.43 ± 0.05 |
***3 | ***3 | |||
***4 | ***4 | |||
FI slope, nAmp/msee | 276.8 ± 17.9 | 293 ± 24.2 | 152.4 ± 18.0 | 154.9 ± 14.1 |
**3 | ***3 | |||
***4 | ***4 | |||
fAHP amplitude, mV | 7.0 ± 1.0 **2 | 3.6 ± 0.8 | 1.5 ± 0.5 | 0.1 ± 0.1 |
***3 | ||||
***4 | *4 | |||
DAP amplitude, mV | 7.2 ± 0.8 ***2 | 2.3 ± 0.4 | 1.2 ± 0.4 | 0.0 ± 0.0 |
***3 | ||||
***4 | *4 |
Values are reported as the means±SE for each class of neurons projecting to the same target. Each class of projection neuron
was assigned a number (1–4) and statistics were calculated from one-way ANOVAs followed by the Scheffe post hoc test to compare
means of pairs of projection neuron classes. Significant differences between pairs are indicated by the P value followed by the projection neuron class (1–4) to which it was compared.
* P < 0.05,
** 0.01,
*** 0.001. CThal, CTrig, and CStr, corticothalamic, corticotrigeminal, and corticostriatal; AP, action potential; FI, firing current; fAHP, fast afterhyperpolarization; DAP, depolarizing afterhyperpolarization.