Control | 100 μM adenosine | Wash | P | |
---|---|---|---|---|
Layer 2 pyramidal neurons (n = 5) | ||||
RMP (mV) | -81.3 ± 1.7 | -81.7 ± 1.7 | - | 0.25 |
Input resistance (MΩ) | 184 ± 29 | 184 ± 27 | 190 ± 30 (n = 4) | 0.96 |
Time constant (ms) | 21.0 ± 2.7 | 22.2 ± 1.9 | 26.1 ± 1.6 (n = 4) | 0.62 |
Rheobase (pA) | 208 ± 30 | 226 ± 49 | 218 ± 40 (n = 4) | 0.44 |
Layer 5 pyramidal neurons (n = 14) | ||||
RMP (mV) | -65.8 ± 1.0 (n = 15) | -69.5 ± 1.1 (n = 15) | - | <0.01 |
Input resistance (MΩ) | 130 ± 16 | 116 ± 14 | 149 ± 2 (n = 12) | 0.04/<0.01 |
Time constant (ms) | 20.3 ± 1.1 | 17.6 ± 1.1 | 24.6 ± 1.7 (n = 12) | 0.04/<0.01 |
Rheobase (pA) | 169 ± 32 | 229 ± 36 | 148 ± 33 (n = 12) | <0.01/<0.01 |
-
Note: Average ± SEM; RMP, resting membrane potential. P lists the results from paired t-tests between control and adenosine. When P < 0.10 the result from the paired t-test between adenosine and wash-out is also given.