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Article: Substance P Activates Ca2+-Permeable Nonselective Cation Channels through a Phosphatidylcholine-Specific Phospholipase C Signaling Pathway in nNOS-Expressing GABAergic Neurons in Visual Cortex.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Endo T; Yanagawa Y; Komatsu Y
Cereb. Cortex, 2014


Table 1

Electrophysiological properties

SP+/nNOS+ (n = 18) SP+/nNOS- (n = 5) SP-/nNOS- (n = 24)
Resting membrane potential (mV) -55.3 ± 1.2**a, b -68.0 ± 4.7 -63.7 ± 1.4
Input resistance (MΩ) 584 ± 46 335 ± 95 519 ± 91
Membrane time constant (ms) 50.9 ± 5.5**b 30.8 ± 9.9 28.7 ± 3.8
Action potential threshold (mV) -45.3 ± 0.7 -50.6 ± 1.3 -45.4 ± 1.1
Action potential amplitude (mV) 77.4 ± 2.3 75.5 ± 1.7 72.4 ± 1.7
Action potential duration (ms) 1.24 ± 0.06*a 0.85 ± 0.12 1.09 ± 0.07
AHP first component amplitude (mV) -15.4 ± 0.7*b -21.4 ± 1.3 -19.8 ± 1.3
AHP first component latency (ms) 5.7 ± 1.3 6.5 ± 2.7 8.3 ± 1.3
AHP second component amplitude (mV) -16.3 ± 1.0 (n = 13) -18.8 (n = 1) -15.8 ± 2.1 (n = 7)
AHP second component latency (ms) 27.4 ± 4.1 (n = 13) 15.4 (n = 1) 21.1 ± 2.5 (n = 7)
  • Note: Statistical significance was assessed by Tukey-Kramer test.

  • aComparison to SP+/nNOS-.

  • bComparison to SP-/nNOS-.

  • *P < 0.05; **P < 0.01.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other Visual cortex neuronal nitric oxide synthase-positive and substance P-positive GABAergic inhibitory interneurons membrane time constant (ms) 50.9 ± 5.5 (18) 50.9 (ms) Data Table
Other Visual cortex substance P-postive GABAergic inhibitory interneurons membrane time constant (ms) 30.8 ± 9.9 (5) 30.8 (ms) Data Table
Other Visual cortex GABAergic inhibitory interneurons membrane time constant (ms) 28.7 ± 3.8 (24) 28.7 (ms) Data Table
Other Visual cortex neuronal nitric oxide synthase-positive and substance P-positive GABAergic inhibitory interneurons spike threshold (mV) -45.3 ± 0.7 (18) -45.3 (mV) Data Table
Other Visual cortex substance P-postive GABAergic inhibitory interneurons spike threshold (mV) -50.6 ± 1.3 (5) -50.6 (mV) Data Table
Other Visual cortex GABAergic inhibitory interneurons spike threshold (mV) -45.4 ± 1.1 (24) -45.4 (mV) Data Table
Other Visual cortex neuronal nitric oxide synthase-positive and substance P-positive GABAergic inhibitory interneurons spike amplitude (mV) 77.4 ± 2.3 (18) 77.4 (mV) Data Table
Other Visual cortex substance P-postive GABAergic inhibitory interneurons spike amplitude (mV) 75.5 ± 1.7 (5) 75.5 (mV) Data Table
Other Visual cortex neuronal nitric oxide synthase-positive and substance P-positive GABAergic inhibitory interneurons resting membrane potential (mV) -55.3 ± 1.2 (18) -55.3 (mV) Data Table
Other Visual cortex GABAergic inhibitory interneurons spike amplitude (mV) 72.4 ± 1.7 (24) 72.4 (mV) Data Table
Other Visual cortex neuronal nitric oxide synthase-positive and substance P-positive GABAergic inhibitory interneurons spike half-width (ms) 1.24 ± 0.06 (18) 1.24 (ms) Data Table
Other Visual cortex substance P-postive GABAergic inhibitory interneurons spike half-width (ms) 0.85 ± 0.12 (5) 0.85 (ms) Data Table
Other Visual cortex GABAergic inhibitory interneurons spike half-width (ms) 1.09 ± 0.07 (24) 1.09 (ms) Data Table
Other Visual cortex neuronal nitric oxide synthase-positive and substance P-positive GABAergic inhibitory interneurons AHP amplitude (mV) -15.4 ± 0.7 (18) 15.4 (mV) Data Table
Other Visual cortex substance P-postive GABAergic inhibitory interneurons AHP amplitude (mV) -21.4 ± 1.3 (5) 21.4 (mV) Data Table
Other Visual cortex GABAergic inhibitory interneurons AHP amplitude (mV) -19.8 ± 1.3 (24) 19.8 (mV) Data Table
Other Visual cortex substance P-postive GABAergic inhibitory interneurons resting membrane potential (mV) -68.0 ± 4.7 (5) -68.0 (mV) Data Table
Other Visual cortex neuronal nitric oxide synthase-positive and substance P-positive GABAergic inhibitory interneurons AHP duration (ms) 5.7 ± 1.3 (18) 5.7 (ms) Data Table
Other Visual cortex substance P-postive GABAergic inhibitory interneurons AHP duration (ms) 6.5 ± 2.7 (5) 6.5 (ms) Data Table
Other Visual cortex GABAergic inhibitory interneurons AHP duration (ms) 8.3 ± 1.3 (24) 8.3 (ms) Data Table
Other Visual cortex GABAergic inhibitory interneurons resting membrane potential (mV) -63.7 ± 1.4 (24) -63.7 (mV) Data Table
Other Visual cortex neuronal nitric oxide synthase-positive and substance P-positive GABAergic inhibitory interneurons input resistance (MΩ) 584.0 ± 46.0 (18) 584.0 (MΩ) Data Table
Other Visual cortex substance P-postive GABAergic inhibitory interneurons input resistance (MΩ) 335.0 ± 95.0 (5) 335.0 (MΩ) Data Table
Other Visual cortex GABAergic inhibitory interneurons input resistance (MΩ) 519.0 ± 91.0 (24) 519.0 (MΩ) Data Table