Table 2
Pharmacological properties of IPSPs generated by presynaptic multipolar and bitufted cells
| Pair | IPSP properties | ||||||||||
| Control | Zolpidem | IAalpha5 | Flum | Zinc | |||||||
| Amp | RT | HW | Amp | RT | HW | Amp | RT | HW | Amp | Amp | |
| Multipolar, nonadapting cells | |||||||||||
| 160805b | 0.34 ± 0.08 | 5.5 | 51 | 0.54 ± 0.1a | 6 | 58 | - | - | - | 0.28 ± 0.06a | - |
| 170805a | 0.23 ± 0.06 | 6 | 56 | 0.39 ± 0.1a | 7 | 62 | - | - | - | 0.18 ± 0.05a | - |
| 130906a | 0.7 ± 0.15 | 4 | 53 | 1.1 ± 0.16a | 5 | 61 | - | - | - | - | - |
| 251006c | 0.84 ± 0.05 | 5 | 57 | - | - | - | 0.83 ± 0.05c | 5 | 56 | - | - |
| 070606a | 1.2 ± 0.32 | 6 | 52 | 2.0 ± 0.43a | 6.2 | 58 | 1.15 ± 0.3c | 5.8 | 52 | 1.0 ± 0.2a | |
| Mean ± SD | 0.6 ± 0.38 mV | 5.2 ± 0.76 ms | 53.5 ± 2.4 ms | +82 ± 30%b | +13 ± 9%d | +18 ± 9%b | -1.0, -1.0% | -19 ± 2.2% | - | ||
| Multipolar, adapting cells | |||||||||||
| 230806a | 0.73 ± 0.2 | 8 | 60 | 1.0 ± 0.3a | 8 | 75 | 0.73 ± 0.2c | 8 | 60 | - | - |
| 130906b | 2.3 ± 0.3 | 10 | 83 | 3.5 ± 0.6a | 11 | 95 | - | - | - | - | - |
| 150906a | 1.3 ± 0.2 | 10 | 110 | 1.6 ± 0.25a | 11 | 150 | - | - | - | 0.9 ± 0.15a | - |
| 160805a | 0.2 ± 0.07 | 7 | 55 | 0.3 ± 0.1a | 8 | 60 | - | - | - | - | - |
| 181005 | 2.8 ± 0.44 | 11 | 155 | 3.8 ± 0.6a | 11 | 211 | - | - | - | - | - |
| 210306b | 0.76 ± 0.25 | 8 | 60 | - | - | - | 0.74 ± 0.3c | 8 | 60 | - | - |
| 191005b | 2.1 ± 0.42 | 8 | 60 | - | - | - | 2.1 ± 0.43c | 6 | 60 | - | - |
| 021106a | 0.44 ± 0.1 | 7 | 80 | - | 7 | 80 | 0.43 ± 0.1c | - | - | - | - |
| 251006c | 0.82 ± 0.26 | 8 | 63 | - | - | - | - | - | - | - | 0.82±0.27c |
| Mean ± SD | 1.2 ± 0.92 mV | 9 ± 1.4 ms | 82 ± 31 ms | +36 ± 14%b | +6 ± 6%d | +20 ± 14%d | -2.0 ± 1 %d | 0% | 0% | -44% | 0% |
| Bitufted, dendrite-preferring cells | |||||||||||
| 191005c | 0.5 ± 0.15 | 17 | 100 | 0.52 ± 0.16c | 17 | 99 | - | - | - | - | - |
| 251005a | 0.7 ± 0.27 | 19 | 130 | - | - | - | 0.6 ± 0.22a | 12 | 110 | - | - |
| 251005b | 1.0 ± 0.38 | 13 | 115 | 1.1 ± 0.4c | 13 | 115 | 0.7 ± 0.28a | 9 | 75 | - | - |
| 061205a | 1.2 ± 0.38 | 12 | 68 | - | - | - | 0.7 ± 0.24a | 12 | 60 | - | - |
| 120106d | 0.6 ± 0.44 | 20 | 125 | - | - | - | 0.2 ± 015a | 21 | 95 | - | - |
| 200106a | 0.75 ± 0.08 | 15 | 114 | - | - | - | 0.5 ± 0.07a | 15 | 70 | - | - |
| 150906b | 0.7 ± 0.27 | 14 | 52 | 0.71 ± 0.28c | 14 | 53 | 0.5 ± 0.2a | 8 | 60 | - | - |
| 251006a | 1.7 ± 0.25 | 14 | 70 | - | - | - | - | - | - | - | 1.2 ± 0.20a |
| 161106a | 0.91 ± 0.3 | 12 | 96 | 0.92 ± 0.3c | 12 | 98 | - | - | - | - | - |
| 060307a | 1.1 ± 0.18 | 14 | 96 | - | - | - | - | - | - | - | 0.9 ± 0.14a |
| 010307a | 0.72 ± 0.2 | 12 | 89 | - | - | - | - | - | - | - | 0.53 ± 0.14a |
| Mean ± SD (%) | 0.81 ± 0.4 mV | 14.7 ± 3.0 ms | 96.3 ± 24 ms | +7.8 ± 5.7%d | 0% | +1 ± 1%d | -35 ± 15%b | -21 ± 18.3 %d | -24.1 ± 10.5%d | - | -24 ± 5% |
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Mean ± standard deviation (SD) of percentage change are given.
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Amp = amplitude (mV), RT = 10-90% rise time (ms), HW = width at half amplitude (ms), + = increase, - = decrease.
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↵a Significantly different from control, unpaired t-test, P ≤ 0.05, shown in bold.
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↵b Significantly different from control, paired t-test, P ≤ 0.05, shown in bold.
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↵c Not significantly different from the control, unpaired t-test, P ≥ 0.05.
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↵d Not significantly different from the control, paired t-test, P ≥ 0.05.