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Article: Morphological and physiological characterization of pyramidal neuron subtypes in rat medial prefrontal cortex.

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van Aerde KI; Feldmeyer D
Cereb. Cortex, 2015


Table 7

Morphological subtypes in L6 differ only marginally in electrophysiological properties

Tall L6 Wide L6 Short L6 Small L6 P
Morphology N = 5 N = 3 N = 5 N = 5
Location in L6 (%) 31% ± 6% 13% ± 8% 49% ± 17% 30% ± 9% 0.28
Field span apical dendrites (μm) 295 ± 27 201 ± 63 361 ± 127 147 ± 10 0.22
Field span basal dendrites (μm) 215 ± 8 751 ± 184** 300 ± 10 181 ± 8 <0.01
Total length apical dendrites (μm) 3853 ± 371* 1930 ± 329 2470 ± 533 1083 ± 144 <0.01
Total length basal dendrites (μm) 1685 ± 250 3387 ± 487* 2464 ± 187* 1597 ± 131 <0.01
Soma (μm2) 186 ± 20 189 ± 24 218 ± 24 185 ± 9 0.57
Number of apical branches 25.2 ± 2.5* 9.0 ± 3.6 15.0 ± 4.5 13.6 ± 2.1 0.03*
Number of basal branches 19.6 ± 2.8 17.3 ± 3.8 21.2 ± 3.6 18.0 ± 3.1 0.85
Vertical span (ending layer) 5 × L1 2 × L1
1 × L3 		2 × L3
1 × L5
2 × L6 		4 × L5
1 × L6 		<0.01
Electrophysiology N = 4 N = 3 N = 4 N = 2
Ratio ISI-1/ISI-9 0.49 ± 0.05 0.35 ± 0.14 0.42 ± 0.12 1.06 ± 0.42 0.53
Ratio ISI-2/ISI-9 0.79 ± 0.07 0.58 ± 0.15 0.66 ± 0.19 1.28 ± 0.39 0.27
Ratio ISI-3/ISI-9 0.93 ± 0.03 0.88 ± 0.06 1.12 ± 0.14 1.35 ± 0.20 0.08
Increase in firing frequency (Hz/100 pA) 15.6 ± 1.5 12.2 ± 1.8 11.6 ± 1.8 24.8 ± 1.3 0.64
Membrane potential (mV) -68.1 ± 1.9 -66.8 ± 0.8 -75.2 ± 2.9 -76.1 ± 1.3 0.01*
Input resistance (MΩ) 276 ± 47 354 ± 85 236 ± 18 433 ± 40 0.67
Rheobase (pA) 78 ± 22 60 ± 10 125 ± 23 65 ± 5 0.32
Time constant (ms) 29.7 ± 4.0 33.1 ± 1.7 21.4 ± 4.7 21.8 ± 5.5 0.09
Voltage sag (%) 10.3 ± 2.5 13.1 ± 3.9 4.4 ± 2.9 6.9 ± 1.4 0.11

  • Note: For clarity, the results of the post hoc comparison of groups is only given (values in bold followed with asterisks) when a cell type is different from all other cell types. *P < 0.05, **P < 0.01. Note that, for vertical span, the χ2 test was used. In the comparison of electrophysiological properties, “short” and “small” L6 pyramidal neurons were grouped to increase the number of observations. Short and small L6 pyramidal neurons are 2 subdivisions of the third cluster of the CA.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 medial prefrontal cortex layer VI pyramidal neuron projecting to layer I adaptation ratio 0.49 ± 0.05 (5) -- Data Table
Neocortex pyramidal cell layer 5-6 medial prefrontal cortex layer IV pyramidal neuron adaptation ratio 0.35 ± 0.14 (3) -- Data Table
Neocortex pyramidal cell layer 5-6 medial prefrontal cortex layer VI pyramidal neuron projecting to layers III - VI adaptation ratio 0.42 ± 0.12 (5) -- Data Table
Neocortex pyramidal cell layer 5-6 medial prefrontal cortex layer VI pyramidal neuron projecting to layers III - VI adaptation ratio 1.06 ± 0.42 (5) -- Data Table
Neocortex pyramidal cell layer 5-6 medial prefrontal cortex layer VI pyramidal neuron projecting to layer I resting membrane potential (mV) -68.1 ± 1.9 (5) -- Data Table
Neocortex pyramidal cell layer 5-6 medial prefrontal cortex layer IV pyramidal neuron resting membrane potential (mV) -66.8 ± 0.8 (3) -- Data Table
Neocortex pyramidal cell layer 5-6 medial prefrontal cortex layer VI pyramidal neuron projecting to layers III - VI resting membrane potential (mV) -75.2 ± 2.9 (5) -- Data Table
Neocortex pyramidal cell layer 5-6 medial prefrontal cortex layer VI pyramidal neuron projecting to layers III - VI resting membrane potential (mV) -76.1 ± 1.3 (5) -- Data Table
Neocortex pyramidal cell layer 5-6 medial prefrontal cortex layer VI pyramidal neuron projecting to layer I input resistance (MΩ) 276.0 ± 47.0 (5) -- Data Table
Neocortex pyramidal cell layer 5-6 medial prefrontal cortex layer IV pyramidal neuron input resistance (MΩ) 354.0 ± 85.0 (3) -- Data Table
Neocortex pyramidal cell layer 5-6 medial prefrontal cortex layer VI pyramidal neuron projecting to layers III - VI input resistance (MΩ) 236.0 ± 18.0 (5) -- Data Table
Neocortex pyramidal cell layer 5-6 medial prefrontal cortex layer VI pyramidal neuron projecting to layers III - VI input resistance (MΩ) 433.0 ± 40.0 (5) -- Data Table
Neocortex pyramidal cell layer 5-6 medial prefrontal cortex layer VI pyramidal neuron projecting to layer I rheobase (pA) 78.0 ± 22.0 (5) -- Data Table
Neocortex pyramidal cell layer 5-6 medial prefrontal cortex layer IV pyramidal neuron rheobase (pA) 60.0 ± 10.0 (3) -- Data Table
Neocortex pyramidal cell layer 5-6 medial prefrontal cortex layer VI pyramidal neuron projecting to layers III - VI rheobase (pA) 125.0 ± 23.0 (5) -- Data Table
Neocortex pyramidal cell layer 5-6 medial prefrontal cortex layer VI pyramidal neuron projecting to layers III - VI rheobase (pA) 65.0 ± 5.0 (5) -- Data Table
Neocortex pyramidal cell layer 5-6 medial prefrontal cortex layer VI pyramidal neuron projecting to layer I membrane time constant (ms) 29.7 ± 4.0 (5) -- Data Table
Neocortex pyramidal cell layer 5-6 medial prefrontal cortex layer IV pyramidal neuron membrane time constant (ms) 33.1 ± 1.7 (3) -- Data Table
Neocortex pyramidal cell layer 5-6 medial prefrontal cortex layer VI pyramidal neuron projecting to layers III - VI membrane time constant (ms) 21.4 ± 4.7 (5) -- Data Table
Neocortex pyramidal cell layer 5-6 medial prefrontal cortex layer VI pyramidal neuron projecting to layers III - VI membrane time constant (ms) 21.8 ± 5.5 (5) -- Data Table