Article: Eag Domains Regulate LQT Mutant hERG Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
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Liu QN; Trudeau MC
PLoS ONE, 2015
10.1371/journal.pone.0123951.t001
Steady-state activation properties for adenoviral hERG1a, hERG1a(R56Q) and hERG1a(R56Q)+ i-eag.Ad in HEK293 cells and hiPSC-CMs.
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| Groups |
HEK293 cells |
Human iPSC-CM |
n |
| V1/2 |
k |
V1/2 |
k |
|
| hERG1a.Ad |
-4.44 ± 1.53 |
8.55 ± 0.33 |
6.50 ± 1.00 |
6.16 ± 0.57 |
13-16 |
| hERG1a(R56Q).Ad |
-3.34 ± 1.07 |
9.00 ± 0.53 |
3.12 ± 1.08 |
6.92 ± 0.23 |
13-18 |
| hERG1a(R56Q).Ad+ i-eag.Ad |
-9.23 ± 0.86 |
9.23 ± 0.63 |
3.84 ± 1.04 |
7.01 ± 0.24 |
18 |
Inferred neuron-electrophysiology data values
| Neuron Type |
Neuron Description |
Ephys Prop |
Extracted Value |
Standardized Value |
Content Source |
