|
Article: Eag Domains Regulate LQT Mutant hERG Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Liu QN; Trudeau MC PLoS ONE, 2015
| Groups | voltage | HEK293 cell | Human iPSC-CM | ||
|---|---|---|---|---|---|
| (mV) | τfast(ms) | τslow(ms) | τfast(ms) | τslow(ms) | |
| hERG1a.Ad | -120 | 50.1 ± 4.5 | 796.2 ± 92.0 | 29.6 ± 5.0 | 39.7 ± 6.0 |
| -100 | 97.4 ± 8.9 | 1043.5 ± 89.0 | 53.0 ± 10.1 | 118.6 ± 23.4 | |
| -80 | 166.5 ± 45.7 | 562.9 ± 58.9 | 145.8 ± 31.6 | 1587.5 ± 325.0 | |
| -60 | 224.4 ± 10.7 | 1125.8 ± 110.2 | 236.8 ± 21.6 | 1428.9 ± 157.7 | |
| -40 | 303.6 ± 19.5 | 1878.2 ± 109.4 | 329.4 ± 30.7 | 2399.7 ± 129.8 | |
| -20 | 477.4 ± 59.2 | 2328.2 ± 232.8 | 1651.5 ± 333.2 | 2148.6 ± 189.5 | |
| hERG1a (R56Q).Ad | -120 | 14.8 ± 3.7 |
218.3 ± 58.1 |
17.3 ± 2.3 | 23.4 ± 3.7 |
| -100 | 22.6 ± 4.9 |
269.8 ± 67.4 |
21.1 ± 2.3 |
29.3 ± 5.1 |
|
| -80 | 29.2 ± 2.5 |
215.3 ± 26.0 |
31.9 ± 3.3 |
96.2 ± 28.9 |
|
| -60 | 56.2 ± 6.3 |
286.3 ± 28.8 |
54.2 ± 3.9 |
256.7 ± 25.0 |
|
| -40 | 90.7 ± 4.9 |
567.6 ± 60.6 |
96.6 ± 7.0 |
602.6 ± 42.8 |
|
| -20 | 149.1 ± 8.4 |
1029.9 ± 63.8 |
196.1 ± 15.9 |
1268.1 ± 72.2 |
|
| hERG1a(R56Q).Ad + i-eag.Ad | -120 | 25.1 ± 3.4 | 339.1 ± 89.7 | 29.8 ± 5.3 | 28.7 ± 4.2 |
| -100 | 41.4 ± 5.8 |
344.3 ± 68.4 | 43.2 ± 7.7 |
49.2 ± 7.3 |
|
| -80 | 48.5 ± 14.4 | 263.4 ± 28.7 | 70.0 ± 10.1 |
306.1 ± 83.3 |
|
| -60 | 106.6 ± 11.8 |
421.2 ± 38.1 |
132.6 ± 14.6 |
652.5 ± 87.9 |
|
| -40 | 183.9 ± 22.2 |
996.4 ± 108.9 |
243.5 ± 23.2 |
1530.2 ± 96.8 |
|
| -20 | 306.9 ± 42.4 |
1782.8 ± 296.3 |
326.3 ± 20.4 |
2339.1 ± 132.6 |
|
*p<0.05 vs. hERG1a.Ad;
#p <0.05 vs. hERG1a (R56Q).Ad. Number of cells for each group is between 6~14, 5~19 and 6~18, respectively.
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|