AboutNeuron TypesElectrophysiology PropertiesArticlesFAQsData/APIGet Involved

Article: Excitability and synaptic alterations in the cerebellum of APP/PS1 mice.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Hoxha E; Boda E; Montarolo F; Parolisi R; Tempia F
PLoS ONE, 2012


10.1371/journal.pone.0034726.t001 Comparison of passive and active membrane properties of wild-type versus APP/PS1 mice of 8 and of 2 months of age.
Spontaneous firing frequency without blockers (Hz) Input resistance (MΩ) IH -dependent voltage deflection (mV) First spike latency (ms) 1st ISI (ms) 2nd ISI (ms) 3rd ISI (ms) Threshold (mV) 1st AP amplitude (mV) AHP amplitude (mV)
Wild-type 8 months n = 14 36.8±5.6 112.9±4.7 41.3±2.5 3.9±0.8 5.0±0.2 8.0±0.9 8.5±1.1 43.3±1.9 88.6±1.6 14.4±1.8
APP/PS1 8 months n = 20 26.4±5.0 109.4±3.6 40.4±1.8 5.5±1.1 6.5±0.1 11.0±1.0 11.7±1.1 41.3±1.6 83.6±2.2 18.6±1.4
P n.s. n.s. n.s. n.s. n.s. <0.05 <0.05 n.s. n.s. <0.025
Wild-type 2 months n = 8 43.9±20.0 88.1±4.9 47.6±3.0 12.2±3.7 7.4±1.0 9.5±1.2 n.a. 52.0±3.1 82.7±4.1 21.5±2.3
APP/PS1 2 months n = 10 45.1±13.6 93.4±4.9 54.5±4.3 12.0±2.7 8.2±0.7 11.7±2.0 n.a. 54.7±2.0 82.3±2.2 18.4±1.8
P n.s. n.s. n.s. n.s. n.s. n.s. n.a. n.s. n.s. n.s.

Report miscurated data

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Cerebellum Purkinje cell firing frequency (Hz) 36.8 ± 5.6 (14) 36.8 (Hz) Data Table
Cerebellum Purkinje cell input resistance (MΩ) 112.9 ± 4.7 (14) 112.9 (MΩ) Data Table
Cerebellum Purkinje cell sag amplitude (mV) 41.3 ± 2.5 (14) 41.3 (mV) Data Table
Cerebellum Purkinje cell first spike latency (ms) 3.9 ± 0.8 (14) 3.9 (ms) Data Table
Cerebellum Purkinje cell spike threshold (mV) 43.3 ± 1.9 (14) -43.3 (mV) Data Table
Cerebellum Purkinje cell spike amplitude (mV) 88.6 ± 1.6 (14) 88.6 (mV) Data Table
Cerebellum Purkinje cell AHP amplitude (mV) 14.4 ± 1.8 (14) 14.4 (mV) Data Table
Cerebellum Purkinje cell firing frequency (Hz) 43.9 ± 20.0 (8) 43.9 (Hz) Data Table
Cerebellum Purkinje cell input resistance (MΩ) 88.1 ± 4.9 (8) 88.1 (MΩ) Data Table
Cerebellum Purkinje cell sag amplitude (mV) 47.6 ± 3.0 (8) 47.6 (mV) Data Table
Cerebellum Purkinje cell first spike latency (ms) 12.2 ± 3.7 (8) 12.2 (ms) Data Table
Cerebellum Purkinje cell spike threshold (mV) 52.0 ± 3.1 (8) -52.0 (mV) Data Table
Cerebellum Purkinje cell spike amplitude (mV) 82.7 ± 4.1 (8) 82.7 (mV) Data Table
Cerebellum Purkinje cell AHP amplitude (mV) 21.5 ± 2.3 (8) 21.5 (mV) Data Table