Article: Excitability and synaptic alterations in the cerebellum of APP/PS1 mice.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Hoxha E; Boda E; Montarolo F; Parolisi R; Tempia F PLoS ONE, 2012
Spontaneous firing frequency without blockers (Hz) | Input resistance (MΩ) | First spike latency (ms) | 1st ISI (ms) | 2nd ISI (ms) | 3rd ISI (ms) | Threshold (mV) | 1st AP amplitude (mV) | AHP amplitude (mV) | ||
Wild-type 8 months n = 14 | 36.8±5.6 | 112.9±4.7 | 41.3±2.5 | 3.9±0.8 | 5.0±0.2 | 8.0±0.9 | 8.5±1.1 | 43.3±1.9 | 88.6±1.6 | 14.4±1.8 |
APP/PS1 8 months n = 20 | 26.4±5.0 | 109.4±3.6 | 40.4±1.8 | 5.5±1.1 | 6.5±0.1 | 11.0±1.0 | 11.7±1.1 | 41.3±1.6 | 83.6±2.2 | 18.6±1.4 |
P | n.s. | n.s. | n.s. | n.s. | n.s. | <0.05 | <0.05 | n.s. | n.s. | <0.025 |
Wild-type 2 months n = 8 | 43.9±20.0 | 88.1±4.9 | 47.6±3.0 | 12.2±3.7 | 7.4±1.0 | 9.5±1.2 | n.a. | 52.0±3.1 | 82.7±4.1 | 21.5±2.3 |
APP/PS1 2 months n = 10 | 45.1±13.6 | 93.4±4.9 | 54.5±4.3 | 12.0±2.7 | 8.2±0.7 | 11.7±2.0 | n.a. | 54.7±2.0 | 82.3±2.2 | 18.4±1.8 |
P | n.s. | n.s. | n.s. | n.s. | n.s. | n.s. | n.a. | n.s. | n.s. | n.s. |