Article: Excitability and synaptic alterations in the cerebellum of APP/PS1 mice.
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Article Data (extracted)
Hoxha E; Boda E; Montarolo F; Parolisi R; Tempia F
PLoS ONE, 2012
10.1371/journal.pone.0034726.t002
Comparison of synaptic parameters of wild-type versus APP/PS1 mice of 8 months of age.
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evoked IPSC amplitude (pA) |
evoked IPSC CV |
evoked IPSC CV-2 |
miniature IPSC amplitude (pA) |
miniature IPSC frequency (Hz) |
Muscimol-evoked current (nA) |
CF_EPSC amplitude (nA) |
CF-EPSC PPD at 200 ms (%) |
PF_EPSC amplitude at 9 µA (pA) |
Wild-type 8 months |
218.6±41.8 n = 10 |
0.48±0.06 n = 10 |
6.82±1.65 n = 10 |
73.8±7.0 n = 24 |
0.58±0.08 n = 24 |
1.52±0.14 n = 14 |
0.94±0.11 n = 12 |
79.1±0.9 n = 12 |
318.8±48.5 n = 17 |
APP/PS1 8 months |
250.8±39.4 n = 11 |
0.42±0.03 n = 11 |
7.04±1.56 n = 11 |
68.9±4.9 n = 31 |
0.60±0.09 n = 31 |
1.48±0.18 n = 14 |
1.49±0.50 n = 10 |
83.0±0.7 n = 10 |
361.5±34.8 n = 14 |
Single data points P (Student's t test) |
n.s. |
n.s. |
n.s. |
n.s. |
n.s. |
n.s. |
n.s. |
<0.01 |
n.s. |
Cumulative distribution P (Kolmogorov-Smirnov test) |
- |
- |
- |
<0.001 |
<0.001 |
- |
- |
- |
- |
Inferred neuron-electrophysiology data values
Neuron Type |
Neuron Description |
Ephys Prop |
Extracted Value |
Standardized Value |
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