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Article: Excitability and synaptic alterations in the cerebellum of APP/PS1 mice.

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Hoxha E; Boda E; Montarolo F; Parolisi R; Tempia F
PLoS ONE, 2012


10.1371/journal.pone.0034726.t002 Comparison of synaptic parameters of wild-type versus APP/PS1 mice of 8 months of age.
evoked IPSC amplitude (pA) evoked IPSC CV evoked IPSC CV-2 miniature IPSC amplitude (pA) miniature IPSC frequency (Hz) Muscimol-evoked current (nA) CF_EPSC amplitude (nA) CF-EPSC PPD at 200 ms (%) PF_EPSC amplitude at 9 µA (pA)
Wild-type 8 months 218.6±41.8 n = 10 0.48±0.06 n = 10 6.82±1.65 n = 10 73.8±7.0 n = 24 0.58±0.08 n = 24 1.52±0.14 n = 14 0.94±0.11 n = 12 79.1±0.9 n = 12 318.8±48.5 n = 17
APP/PS1 8 months 250.8±39.4 n = 11 0.42±0.03 n = 11 7.04±1.56 n = 11 68.9±4.9 n = 31 0.60±0.09 n = 31 1.48±0.18 n = 14 1.49±0.50 n = 10 83.0±0.7 n = 10 361.5±34.8 n = 14
Single data points P (Student's t test) n.s. n.s. n.s. n.s. n.s. n.s. n.s. <0.01 n.s.
Cumulative distribution P (Kolmogorov-Smirnov test) - - - <0.001 <0.001 - - - -

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