TABLE 1.Slice data: first AP during 3-s current injections
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| RMP | AP | Width | HW | dV/dt |
Vth | |||
| Up | Down | |||||||
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| Control | –73 ± 4.8 (n = 14) | 101 ± 5.7 (n = 14) | 4.9 ± 1.6 (n = 14) | 2.7 ± 0.8 (n = 14) | 159 ± 64 (n = 14) | 34 ± 14 (n = 14) | –39 ± 5.9 (n = 20) | |
| DTX | –73 ± 4.9 (n = 14) | 98 ± 6.2 (n = 14) | 6.1 ± 2.9 (n = 14)* | 2.6 ± 0.6 (n = 14) | 158 ± 62 (n = 14) | 34 ± 19 (n = 14) | –41 ± 5.8 (n = 20)* | |
Values are means ± SD; values of n (whole cell recordings) are in parentheses. RMP, resting membrane potential (mV); AP, action potential amplitude from resting
membrane potential (mV); HW, AP width at half amplitude [(peak – RMP)/2] (ms); Width, AP width at Vth (ms); Vth, voltage threshold
for AP initiation (mV). Statistical significance:
* P < 0.05.