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Article: Delayed effects of corticosterone on slow after-hyperpolarization potentials in mouse hippocampal versus prefrontal cortical pyramidal neurons.

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Pillai AG; Henckens MJ; Fernández G; Joëls M
PLoS ONE, 2014


10.1371/journal.pone.0099208.t001 Active and passive properties of neurons within each of the limbic brain regions were not significantly different between treatment (vehicle and corticosterone) groups.
Hippocampus (CA1) Orbital frontal Cortex (layer 2/3) Prelimbic Cortex (Layer 2/3) Infralimbic cortex (layer 2/3)
Vehicle Cort Vehicle Cort Vehicle Cort Vehicle Cort
No. of cells 20 13 21 14 20 17 21 15
Resting membrane potential (mV) -71.6±0.9 -72.4±1.4 -75.1±1.5 -74.5±1.7 -73.0±1.6 -73.8±1.3 -74.1±1.0 -72.8±1.3
Input resistance (MΩ) 230.0±14 217.5±24 162.8±12 174.8±17 242.1±17 259.9±24 316.9±21 294.9±22
Membrane time constant (ms) 30.5±1.7 26±1.6 29.5±3.1 36.9±3.3 44.6±2.4 39.8±2.8 48.7±2.4 43.9±3.1
Action potential amplitude (mV) 60.0±1.3 57.0±1.5 54.7±1.4 54.8±1.4 54.9±1.4 54.8±1.2 54.7±0.7 55.0±0.8
Action potential rise time (µs) 167±10 152±5 156±7 166±9 180±7 185±6 200±9 199±10
Action potential rising slope (mV/ms) 423.9±19 423.8±15 355.1±14 341.5±15 313.3±18 305.6±15 290.0±14 298.0±19
Action-potential threshold (mV) -50.4±1.0 -49.3±1.5 -36.9±1 -38.0±1.1 -35.8±1.3 -37.3±0.8 -36.9±0.7 -37.5±1.1
Action potential width at half maximum (ms) 1.49±0.05 1.42±0.04 0.94±0.05 0.99.±0.06 1.11±0.05 1.11±0.04 1.11±0.04 1.11±0.05
mAHP decay (ms) 105±10 122±17 254±17 214±22 228±22 239±20 174±20 197±23
sAHP decay (sec) 7.8±0.3 7.3±0.4 6.5±0.3 7.2±0.3 5.4±0.6 5.6±0.5 6.2±0.5 5.4±0.6

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 2-3 Prelimbic cortex layer 2-3 pyramidal cell medium AHP duration (ms) 228.0 ± 22.0 (20) 228.0 (ms) Data Table
Neocortex pyramidal cell layer 2-3 infralimbic cortex layer 2-3 pyramidal cell medium AHP duration (ms) 174.0 ± 20.0 (21) 174.0 (ms) Data Table
Hippocampus CA1 pyramidal cell slow AHP duration (sec) 7.8 ± 0.3 (20) 7800.0 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Orbital frontal cortex layer 2-3 pyramidal cell slow AHP duration (sec) 6.5 ± 0.3 (21) 6500.0 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Prelimbic cortex layer 2-3 pyramidal cell slow AHP duration (sec) 5.4 ± 0.6 (20) 5400.0 (ms) Data Table
Neocortex pyramidal cell layer 2-3 infralimbic cortex layer 2-3 pyramidal cell slow AHP duration (sec) 6.2 ± 0.5 (21) 6200.0 (ms) Data Table
Hippocampus CA1 pyramidal cell resting membrane potential (mV) -71.6 ± 0.9 (20) -71.6 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Orbital frontal cortex layer 2-3 pyramidal cell resting membrane potential (mV) -75.1 ± 1.5 (21) -75.1 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Prelimbic cortex layer 2-3 pyramidal cell resting membrane potential (mV) -73.0 ± 1.6 (20) -73.0 (mV) Data Table
Neocortex pyramidal cell layer 2-3 infralimbic cortex layer 2-3 pyramidal cell resting membrane potential (mV) -74.1 ± 1.0 (21) -74.1 (mV) Data Table
Hippocampus CA1 pyramidal cell input resistance (MΩ) 230.0 ± 14.0 (20) 230.0 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 Orbital frontal cortex layer 2-3 pyramidal cell input resistance (MΩ) 162.8 ± 12.0 (21) 162.8 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 Prelimbic cortex layer 2-3 pyramidal cell input resistance (MΩ) 242.1 ± 17.0 (20) 242.1 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 infralimbic cortex layer 2-3 pyramidal cell input resistance (MΩ) 316.9 ± 21.0 (21) 316.9 (MΩ) Data Table
Hippocampus CA1 pyramidal cell membrane time constant (ms) 30.5 ± 1.7 (20) 30.5 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Orbital frontal cortex layer 2-3 pyramidal cell membrane time constant (ms) 29.5 ± 3.1 (21) 29.5 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Prelimbic cortex layer 2-3 pyramidal cell membrane time constant (ms) 44.6 ± 2.4 (20) 44.6 (ms) Data Table
Neocortex pyramidal cell layer 2-3 infralimbic cortex layer 2-3 pyramidal cell membrane time constant (ms) 48.7 ± 2.4 (21) 48.7 (ms) Data Table
Hippocampus CA1 pyramidal cell spike amplitude (mV) 60.0 ± 1.3 (20) 60.0 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Orbital frontal cortex layer 2-3 pyramidal cell spike amplitude (mV) 54.7 ± 1.4 (21) 54.7 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Prelimbic cortex layer 2-3 pyramidal cell spike amplitude (mV) 54.9 ± 1.4 (20) 54.9 (mV) Data Table
Neocortex pyramidal cell layer 2-3 infralimbic cortex layer 2-3 pyramidal cell spike amplitude (mV) 54.7 ± 0.7 (21) 54.7 (mV) Data Table
Hippocampus CA1 pyramidal cell spike rise time 167.0 ± 10.0 (20) -- Data Table
Neocortex pyramidal cell layer 2-3 Orbital frontal cortex layer 2-3 pyramidal cell spike rise time 156.0 ± 7.0 (21) -- Data Table
Neocortex pyramidal cell layer 2-3 Prelimbic cortex layer 2-3 pyramidal cell spike rise time 180.0 ± 7.0 (20) -- Data Table
Neocortex pyramidal cell layer 2-3 infralimbic cortex layer 2-3 pyramidal cell spike rise time 200.0 ± 9.0 (21) -- Data Table
Hippocampus CA1 pyramidal cell spike max rise slope (mV/ms) 423.9 ± 19.0 (20) 423.9 (mV/ms) Data Table
Neocortex pyramidal cell layer 2-3 Orbital frontal cortex layer 2-3 pyramidal cell spike max rise slope (mV/ms) 355.1 ± 14.0 (21) 355.1 (mV/ms) Data Table
Neocortex pyramidal cell layer 2-3 Prelimbic cortex layer 2-3 pyramidal cell spike max rise slope (mV/ms) 313.3 ± 18.0 (20) 313.3 (mV/ms) Data Table
Neocortex pyramidal cell layer 2-3 infralimbic cortex layer 2-3 pyramidal cell spike max rise slope (mV/ms) 290.0 ± 14.0 (21) 290.0 (mV/ms) Data Table
Hippocampus CA1 pyramidal cell spike threshold (mV) -50.4 ± 1.0 (20) -50.4 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Orbital frontal cortex layer 2-3 pyramidal cell spike threshold (mV) -36.9 ± 1.0 (21) -36.9 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Prelimbic cortex layer 2-3 pyramidal cell spike threshold (mV) -35.8 ± 1.3 (20) -35.8 (mV) Data Table
Neocortex pyramidal cell layer 2-3 infralimbic cortex layer 2-3 pyramidal cell spike threshold (mV) -36.9 ± 0.7 (21) -36.9 (mV) Data Table
Hippocampus CA1 pyramidal cell spike half-width (ms) 1.49 ± 0.05 (20) 1.49 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Orbital frontal cortex layer 2-3 pyramidal cell spike half-width (ms) 0.94 ± 0.05 (21) 0.94 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Prelimbic cortex layer 2-3 pyramidal cell spike half-width (ms) 1.11 ± 0.05 (20) 1.11 (ms) Data Table
Neocortex pyramidal cell layer 2-3 infralimbic cortex layer 2-3 pyramidal cell spike half-width (ms) 1.11 ± 0.04 (21) 1.11 (ms) Data Table
Hippocampus CA1 pyramidal cell medium AHP duration (ms) 105.0 ± 10.0 (20) 105.0 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Orbital frontal cortex layer 2-3 pyramidal cell medium AHP duration (ms) 254.0 ± 17.0 (21) 254.0 (ms) Data Table