TABLE 2.Electrophysiological parameters of DCN neurons at room temperature
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Large GAD– |
Small GAD– |
GAD+ |
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Mean | SE | n | Mean | SE | n | Mean | SE | n | |||||||
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Input resistance, MΩ | 220 | 22 | 18 | 572 | 69 | 18 | 1,069 | 91 | 24 | ||||||
Membrane time constant (tau), ms | 33.1 | 4.3 | 18 | 36.8 | 3.7 | 18 | 55.7 | 6.2 | 24 | ||||||
Cm, pF | 141.7 | 7.4 | 18 | 69.2 | 4.3 | 18 | 55.9 | 5.4 | 24 | ||||||
Spontaneous firing frequency (external recording), Hz | 16.9 | 1.9 | 9 | 8.3 | 2.2 | 4 | 9.8 | 1.1 | 16 | ||||||
Spontaneous firing frequency (whole cell), Hz | 30.6 | 5.8 | 13 | 28.5 | 13.2 | 7 | 9.9 | 1.0 | 19 | ||||||
eAP peak Vm, mV | 27.5 | 4.1 | 12 | 28.0 | 11.4 | 17 | 30.2 | 3.3 | 22 | ||||||
eAP half-width, ms | 0.53 | 0.03 | 12 | 0.85 | 0.06 | 17 | 0.99 | 0.05 | 22 | ||||||
ssAP threshold Vm, mV | –35.5 | 2.0 | 11 | –33.1 | 1.4 | 8 | –38.6 | 2.2 | 12 | ||||||
ssAP peak Vm, mV | 10.0 | 2.3 | 11 | 27.1 | 1.1 | 8 | 21.0 | 2.3 | 12 | ||||||
ssAP half-width, ms | 0.74 | 0.07 | 11 | 1.15 | 0.18 | 8 | 1.52 | 0.09 | 12 | ||||||
ssAP fAHP peak time, ms | 4.05 | 0.24 | 11 | 4.6 | 0.30 | 6 | NA | NA | NA | ||||||
ssAP fAHP peak Vm (relative to prespike Vm), mV | –9.1 | 1.1 | 11 | –11.1 | 2.1 | 6 | NA | NA | NA | ||||||
ssAP sAHP peak time, ms | 19.19 | 2.43 | 8 | 31.0 | 2.6 | 7 | 34.7 | 2.1 | 12 | ||||||
ssAP sAHP peak Vm, mV | –9.5 | 0.9 | 9 | –11.7 | 1.06 | 7 | –14.7 | 0.9 | 12 |
Cm, apparent cell capacitance; eAP, evoked action potential, ssAP, steady-state action potential; fAHP, fast afterhyperpolarization;
sAHP, slow afterhyperpolarization. NA, data not available.