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Article: Functional integration of human neural precursor cells in mouse cortex.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Zhou FW; Fortin JM; Chen HX; Martinez-Diaz H; Chang LJ; Reynolds BA; Roper SN
PLoS ONE, 2015


10.1371/journal.pone.0120281.t001 Intrinsic membrane properties and synaptic currents of different types of neurons.
PV CR SS Pyramids
GFP Host GFP Host GFP Host GFP Host
Membrane properties
Rest potential (mV) -73.7±1.2 -74.2±1.5 -70.4±1.4 -71.1±1.5 -74.5±1.6 -73.7±1.4 -74.9±1.5 -75.3±1.7
AP threshold (mV) -48.4±0.9 -47.6±1.1 -51.5±1.7 -49.8±1.5 -47.9±1.1 -48.3±1.2 -51.6±1.3 -50.2±1.2
AP amplitude (mV) 71.3±1.0 72.4±1.3 54.1±2.0 56.9±1.7 69.9±1.4 70.7±1.6 69.5±1.1 70.3±1.4
AP half-width (msec) 0.45±0.03 0.43±0.05 0.86±0.10 0.81±0.12 0.64±0.08 0.62±0.06 1.22±0.09 1.19±0.10
Rinput (MΩ) 170.5±13.4 165.1±14.8 275.6±29.3 281.4±31.5 183.2±21.2 179.9±20.6 194.5±15.5 183.3±14.7
Time constant (msec) 14.4±1.2 13.8±1.5 19.7±1.8 18.6±2.1 15.8±1.7 15.3±1.9 19.1±1.3 19.3±1.4
f-I slope (Hz/nA) 324.4±14.5 338.5±15.5 142.4±16.1 149.6±17.5 101.2±12.4 108.7±13.7 54.8±7.9 59.5±7.3
AP adaptation 0.97±0.07 0.99±0.08 5.63±0.85 5.48±0.91 2.74±0.47 2.63±0.40 2.13±0.24 2.05±0.22
N 25 11 12 10 13 11 11 12
sEPSCs
Frequency (Hz) 9.03±0.55 9.34±0.73 2.31±0.14 2.40±0.18 3.49±0.30 3.68±0.37 6.08±0.42 5.47±0.53
Amplitude (pA) 34.6±1.5 31.7±2.2 24.0±1.8 24.6±2.1 25.8±1.7 26.2±2.1 31.9±2.4 30.7±2.2
Rise time (msec) 1.42±0.09 1.21±0.10 1.47±0.11 1.27±0.12 1.40±0.07 1.22±0.09 1.67±0.12 1.55±0.16
τ(msec) 9.56±0.71 8.58±0.82 9.67±0.80 8.34±0.85 9.09±0.85 8.54±0.83 10.25±0.82 9.18±0.97
N 13 5 6 5 6 6 5 6
sIPSCs
Frequency (Hz) 7.64±0.48 6.69±0.57 2.64±0.21 2.77±0.23 2.77±0.19 2.96±0.25 13.12±1.14 12.78±1.18
Amplitude (pA) 32.2±2.1 28.9±2.5 23.6±1.8 24.4±2.2 24.9±1.7 25.1±2.0 36.4±2.6 34.7±2.8
Rise time (msec) 1.82±0.10 2.14±0.16 1.77±0.12 1.91±0.18 1.85±0.14 2.08±0.15 1.93±0.14 1.99±0.17
τ(msec) 14.27±1.02 16.74±1.42 14.06±1.13 16.75±1.44 14.94±1.16 16.65±1.34 13.47±0.80 12.97±1.16
N 12 6 6 5 7 5 6 6

PV, CR and SS are PV-, CR-, and SS-ir interneurons, respectively; AP, action potential; Rinput, input resistance; f-I slope, slope of the relationship between injected current intensity and firing rate;τ, decay time constant; rise time, 10-90% rise time.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 Neocortex excitatory pyramidal neurons resting membrane potential (mV) -75.3 ± 1.7 (12) -75.3 (mV) Data Table
Neocortex uncharacterized cell Neocortex parvalbumin-expressing GABAergic inhibitory interneurons spike threshold (mV) -47.6 ± 1.1 (11) -47.6 (mV) Data Table
Neocortex uncharacterized cell Neocortex calretinin-expressing GABAergic inhibitory interneurons spike threshold (mV) -49.8 ± 1.5 (10) -49.8 (mV) Data Table
Neocortex uncharacterized cell Neocortex somatostatin-expressing GABAergic inhibitory interneurons spike threshold (mV) -48.3 ± 1.2 (11) -48.3 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Neocortex excitatory pyramidal neurons spike threshold (mV) -50.2 ± 1.2 (12) -50.2 (mV) Data Table
Neocortex uncharacterized cell Neocortex parvalbumin-expressing GABAergic inhibitory interneurons spike amplitude (mV) 72.4 ± 1.3 (11) 72.4 (mV) Data Table
Neocortex uncharacterized cell Neocortex calretinin-expressing GABAergic inhibitory interneurons spike amplitude (mV) 56.9 ± 1.7 (10) 56.9 (mV) Data Table
Neocortex uncharacterized cell Neocortex somatostatin-expressing GABAergic inhibitory interneurons spike amplitude (mV) 70.7 ± 1.6 (11) 70.7 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Neocortex excitatory pyramidal neurons spike amplitude (mV) 70.3 ± 1.4 (12) 70.3 (mV) Data Table
Neocortex uncharacterized cell Neocortex parvalbumin-expressing GABAergic inhibitory interneurons spike half-width (msec) 0.43 ± 0.05 (11) 0.43 (ms) Data Table
Neocortex uncharacterized cell Neocortex calretinin-expressing GABAergic inhibitory interneurons spike half-width (msec) 0.81 ± 0.12 (10) 0.81 (ms) Data Table
Neocortex uncharacterized cell Neocortex somatostatin-expressing GABAergic inhibitory interneurons spike half-width (msec) 0.62 ± 0.06 (11) 0.62 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Neocortex excitatory pyramidal neurons spike half-width (msec) 1.19 ± 0.1 (12) 1.19 (ms) Data Table
Neocortex uncharacterized cell Neocortex parvalbumin-expressing GABAergic inhibitory interneurons resting membrane potential (mV) -74.2 ± 1.5 (11) -74.2 (mV) Data Table
Neocortex uncharacterized cell Neocortex parvalbumin-expressing GABAergic inhibitory interneurons input resistance (MΩ) 165.1 ± 14.8 (11) 165.1 (MΩ) Data Table
Neocortex uncharacterized cell Neocortex calretinin-expressing GABAergic inhibitory interneurons input resistance (MΩ) 281.4 ± 31.5 (10) 281.4 (MΩ) Data Table
Neocortex uncharacterized cell Neocortex somatostatin-expressing GABAergic inhibitory interneurons input resistance (MΩ) 179.9 ± 20.6 (11) 179.9 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Neocortex excitatory pyramidal neurons input resistance (MΩ) 183.3 ± 14.7 (12) 183.3 (MΩ) Data Table
Neocortex uncharacterized cell Neocortex parvalbumin-expressing GABAergic inhibitory interneurons membrane time constant (msec) 13.8 ± 1.5 (11) 13.8 (ms) Data Table
Neocortex uncharacterized cell Neocortex calretinin-expressing GABAergic inhibitory interneurons membrane time constant (msec) 18.6 ± 2.1 (10) 18.6 (ms) Data Table
Neocortex uncharacterized cell Neocortex somatostatin-expressing GABAergic inhibitory interneurons membrane time constant (msec) 15.3 ± 1.9 (11) 15.3 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Neocortex excitatory pyramidal neurons membrane time constant (msec) 19.3 ± 1.4 (12) 19.3 (ms) Data Table
Neocortex uncharacterized cell Neocortex parvalbumin-expressing GABAergic inhibitory interneurons FI slope (Hz/nA) 338.5 ± 15.5 (11) 338.5 (Hz/nA) Data Table
Neocortex uncharacterized cell Neocortex calretinin-expressing GABAergic inhibitory interneurons resting membrane potential (mV) -71.1 ± 1.5 (10) -71.1 (mV) Data Table
Neocortex uncharacterized cell Neocortex calretinin-expressing GABAergic inhibitory interneurons FI slope (Hz/nA) 149.6 ± 17.5 (10) 149.6 (Hz/nA) Data Table
Neocortex uncharacterized cell Neocortex somatostatin-expressing GABAergic inhibitory interneurons FI slope (Hz/nA) 108.7 ± 13.7 (11) 108.7 (Hz/nA) Data Table
Neocortex pyramidal cell layer 5-6 Neocortex excitatory pyramidal neurons FI slope (Hz/nA) 59.5 ± 7.3 (12) 59.5 (Hz/nA) Data Table
Neocortex uncharacterized cell Neocortex parvalbumin-expressing GABAergic inhibitory interneurons adaptation ratio (last/first ISI) 0.99 ± 0.08 (11) 0.99 (ratio) Data Table
Neocortex uncharacterized cell Neocortex calretinin-expressing GABAergic inhibitory interneurons adaptation ratio (last/first ISI) 5.48 ± 0.91 (10) 5.48 (ratio) Data Table
Neocortex uncharacterized cell Neocortex somatostatin-expressing GABAergic inhibitory interneurons adaptation ratio (last/first ISI) 2.63 ± 0.4 (11) 2.63 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Neocortex excitatory pyramidal neurons adaptation ratio (last/first ISI) 2.05 ± 0.22 (12) 2.05 (ratio) Data Table
Neocortex uncharacterized cell Neocortex somatostatin-expressing GABAergic inhibitory interneurons resting membrane potential (mV) -73.7 ± 1.4 (11) -73.7 (mV) Data Table