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Article: Intrinsic membrane plasticity via increased persistent sodium conductance of cholinergic neurons in the rat laterodorsal tegmental nucleus contributes to cocaine-induced addictive behavior.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Kamii H; Kurosawa R; Taoka N; Shinohara F; Minami M; Kaneda K Eur. J. Neurosci., 2015
| Saline-treated | Cocaine-treated | |||
|---|---|---|---|---|
| Regular | Burst | Regular | Burst | |
| No. of neurons (%) | 65 (70.7) | 27 (29.3) | 56 (69.1) | 25 (30.9) |
| RMP (mV) | -71.4 ± 0.6 (n = 41) | -71.7 ± 1.2 (n = 18) | -71.7 ± 0.6 (n = 41) | -71.3 ± 0.8 (n = 19) |
| Spontaneous firing rate (Hz) | 1.4 ± 0.2 (n = 24) | 1.4 ± 0.2 (n = 9) | 1.8 ± 0.3 (n = 15) | 1.5 ± 0.4 (n = 6) |
| Input resistance (MΩ) | 231.0 ± 5.9 | 258.1 ± 11.3 | 284.4 ± 10.2**** | 265.0 ± 10.0 |
| Capacitance (pF) | 22.3 ± 1.1 | 24.1 ± 1.7 | 21.3 ± 1.1 | 26.3 ± 1.9 |
| AP threshold (mV) | -47.3 ± 0.8 | -48.1 ± 0.9 | -49.0 ± 0.7 | -48.7 ± 0.5 |
| AP amplitude (mV) | 64.2 ± 1.0 | 66.5 ± 1.7 | 67.9 ± 1.4 | 68.9 ± 2.2 |
| fAHP amplitude (mV) | 12.7 ± 0.9 | NA | 9.2 ± 1.0# | NA |
| mAHP amplitude (mV) | 21.5 ± 0.8 | NA | 17.6 ± 0.8## | NA |
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Other | laterodorsal tegmental nucleus regular-firing cholinergic neuron | spontaneous firing rate (Hz) | 1.4 ± 0.2 (24) | 1.4 (Hz) | Data Table |
| Other | laterodorsal tegmental nucleus burst-firing cholinergic neuron | spontaneous firing rate (Hz) | 1.4 ± 0.2 (9) | 1.4 (Hz) | Data Table |
| Other | laterodorsal tegmental nucleus regular-firing cholinergic neuron | input resistance (MΩ) | 231.0 ± 5.9 (65) | 231.0 (MΩ) | Data Table |
| Other | laterodorsal tegmental nucleus burst-firing cholinergic neuron | input resistance (MΩ) | 258.1 ± 11.3 (27) | 258.1 (MΩ) | Data Table |
| Other | laterodorsal tegmental nucleus regular-firing cholinergic neuron | cell capacitance (pF) | 22.3 ± 1.1 (65) | 22.3 (pF) | Data Table |
| Other | laterodorsal tegmental nucleus burst-firing cholinergic neuron | cell capacitance (pF) | 24.1 ± 1.7 (27) | 24.1 (pF) | Data Table |
| Other | laterodorsal tegmental nucleus regular-firing cholinergic neuron | spike threshold (mV) | -47.3 ± 0.8 (65) | -47.3 (mV) | Data Table |
| Other | laterodorsal tegmental nucleus burst-firing cholinergic neuron | spike threshold (mV) | -48.1 ± 0.9 (27) | -48.1 (mV) | Data Table |
| Other | laterodorsal tegmental nucleus regular-firing cholinergic neuron | spike amplitude (mV) | 64.2 ± 1.0 (65) | 64.2 (mV) | Data Table |
| Other | laterodorsal tegmental nucleus burst-firing cholinergic neuron | spike amplitude (mV) | 66.5 ± 1.7 (27) | 66.5 (mV) | Data Table |
| Other | laterodorsal tegmental nucleus regular-firing cholinergic neuron | fast AHP amplitude (mV) | 12.7 ± 0.9 (65) | 12.7 (mV) | Data Table |
| Other | laterodorsal tegmental nucleus regular-firing cholinergic neuron | medium AHP amplitude (mV) | 21.5 ± 0.8 (65) | 21.5 (mV) | Data Table |
| Other | laterodorsal tegmental nucleus regular-firing cholinergic neuron | resting membrane potential (mV) | -71.4 ± 0.6 (41) | -71.4 (mV) | Data Table |
| Other | laterodorsal tegmental nucleus burst-firing cholinergic neuron | resting membrane potential (mV) | -71.7 ± 1.2 (18) | -71.7 (mV) | Data Table |