Drug | Time | RN (MΩ) | Vm (mV) | Rheo (pA) | APthresh (mV) | APlatency (ms) | fAHP (mV) | sAHP (mV) |
---|---|---|---|---|---|---|---|---|
NE | Pre | 121 ± 24 | -70 ± 3 | 223 ± 75 | -40 ± 2 | 118 ± 18 | -7.3 ± 0.7 | -0.5 ± 0.2 |
Post | 124 ± 30 | -65 ± 3** | 173 ± 74** | -39 ± 1 | 53 ± 8** | -7.7 ± 1.1 | 0.3 ± 0.2* | |
Prop + NE | Pre | 132 ± 13 | -69 ± 4 | 93 ± 11 | -41 ± 5 | 130 ± 28 | -5.6 ± 1.3 | -0.9 ± 0.3 |
Post | 149 ± 12 | -68 ± 4 | 88 ± 18 | -41 ± 4 | 102 ± 29 | -4.5 ± 1.6 | -0.9 ± 0.3 |
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NE, norepinephrine; Prop, propranolol; RN, input resistance; Vm, resting membrane potential; Rheo, rheobase; APthresh, action potential threshold; APlatency, action potential latency; fAHP, fast afterhyperpolarization; sAHP, slow afterhyperpolarization.
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↵*p < 0.05,
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↵**p < 0.01 as compared with pre-NE application.