Drug | Time | RN (MΩ) | Vm (mV) | Rheo (pA) | APthresh (mV) | APlatency (ms) | fAHP (mV) | sAHP (mV) |
---|---|---|---|---|---|---|---|---|
NE | Pre | 285 ± 56 | -65 ± 2 | 74 ± 15 | -42 ± 2 | 127 ± 35 | -11 ± 0.9 | 0.0 ± 0.1 |
Post | 231 ± 39 | -60 ± 2** | 31 ± 9** | -44 ± 2 | 32 ± 10** | -6.1 ± 1.6** | 0.0 ± 0.2 | |
Prop + NE | Pre | 333 ± 52 | -69 ± 3 | 58 ± 9 | -44 ± 2 | 148 ± 44 | -14.1 ± 1.0 | -0.2 ± 0.2 |
Post | 365 ± 53 | -69 ± 3 | 39 ± 9* | -46 ± 2 | 83 ± 23 | -13.1 ± 1.7 | 0.3 ± 0.4 |
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NE, norepinephrine; Prop, propranolol; RN, input resistance; Vm, resting membrane potential; Rheo, rheobase; APthresh, action potential threshold; APlatency, action potential latency; fAHP, fast afterhyperpolarization; sAHP, slow afterhyperpolarization.
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↵*p < 0.05,
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↵**p < 0.01 as compared with pre-NE application.